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Smoothened is a G protein-coupled receptor of the hedgehog signaling pathway.

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  1. Cat.No. Product Name Information
  2. A8228 Purmorphamine Purmorphamine, a purine derivative, is a Hedgehog agonist. Purmorphamine directly binds to and activates the 7-transmembrane Smo receptor of the Hedgehog signaling pathway.
  3. A3258 BMS-833923 BMS-833923 is an orally bioavailable and selective antagonist of smoothened (SMO) with IC0 value of 5.8 nM in NIH3T3 cell line [1].
  4. C4582 ALLO-1
  5. B5767 GSA 10 New Product
  6. B5766 M 25 New Product
  7. B5674 SMANT hydrochloride New Product
  8. B7685 MRT 10 New Product
  9. B3283 PF-04449913 PF-04449913 is an orally bioavailable inhibitor of smoothened with IC50 value of 5nM .
  10. A3543 LDE225 Diphosphate LDE225 Diphosphate
  11. A3460 HhAntag A small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway. Antitumor agent.

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