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Thrombin is a Na+ -activated allosteric serine protease that catalyzes the formation of thrombus as well as a series of flux-regulating reactions through the coagulation cascade. In response to vascular injury, thrombin is produced through the activation of its inactive precursor, prothrobin, catalyzed by Factor Xa (a trypsin-like proteinase). As a serine protease characterized by the presence of a catalytic triad, thrombin possess a triad of S195-H57-D189 in its active center, which is required for the nucleophilic attack of the target peptide bond. Located “south-west” of the active center is a Na+ -binding site, through which the binding of a sodium ion allosterically modulates the activity of the serine proteinase.

Compare Products

  1. Cat.No. Product Name Information
  2. A3126 5-R-Rivaroxaban Factor Xa (FXa) inhibitor
  3. A4341 Apixaban Factor Xa inhibitor
  4. A8363 Argatroban Thrombin mediated fibrinogen cleavage inhibitor
  5. A4077 BIBR 953 (Dabigatran, Pradaxa) Thrombin inhibitor,potent,reversible and direct
  6. A8381 BIBR-1048 Thrombin inhibitor
  7. A3244 Bivalirudin Trifluoroacetate Reversible thrombin inhibitor
  8. A3345 Dabigatran etexilate mesylate Direct thrombin inhibitor,anticoagulant,prodrug of dabigatran
  9. A3346 Dabigatran ethyl ester Thrombin activity inhibitor
  10. A3381 Edoxaban Factor Xa inhibitor
  11. A3383 Edoxaban tosylate monohydrate Oral factor Xa inhibitor

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