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Gamma Secretase

Gamma secretase (γ-secretase), a member of the intramembrane cleaving protease (i-CLiP) family, is a promiscuous di-aspartyl protease that catalyzes the regulated intramembrane proteolysis (RIP), in which substrate proteins are cleaved within their membrane-spanning domain. A functional γ-secretase is a multi-protein complex consisting of the catalytic component, presenilin (PSEN), and three protein cofactors, including nicastrin (NCT), anterior-pharynx defective-1 (APH1) and PSEN enhancer-2 (PEN2). So far, 90 substrates of γ-secretase have been identified, which are type-I transmembrane proteins, except for glutamate receptor GluR3, polycystin-1 and glucosaminyltransferase (GnT-V), and appear to function as signaling proteins regulating a wide variety of cellular events, such as Notch signaling pathway.

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  1. Cat.No. Product Name Information
  2. A4406 Begacestat γ-secretase inhibitor
  3. A4400 BMS 299897 γ--secretase inhibitor, potent and orally active
  4. A4022 BMS-708163 (Avagacestat) γ-secretase inhibitor
  5. A4401 Compound W γ-secretase inhibitor
  6. A8200 DAPT (GSI-IX) γ-secretase inhibitor,potent and specific
  7. A4402 Flurizan NSAID,inhibits γ-secretase activity
  8. A4403 JLK 6 γ-secretase inhibitor
  9. A4404 L-685,458 γ-secretase inhibitor
  10. A4019 LY-411575 Gamma secretase inhibitor
  11. A4020 LY2811376 Non-peptidic BACE1 inhibitor

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