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Proteases

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for  Proteases

product-structure
  1. Cat.No. Product Name Information
  2. A4057 AUY922 (NVP-AUY922) Potent Hsp90 inhibitor
  3. A4416 AZ 10417808 Caspase-3 inhibitor,selective non-peptide
  4. A3217 Balapiravir Polymerase inhibitor,anti-HCV
  5. A2577 Batimastat (BB-94) MMP inhibitor
  6. C4325 BAY-678 HNE inhibitor
  7. A4444 BC 11 hydrobromide Selective urokinase inhibitor
  8. A4406 Begacestat γ-secretase inhibitor
  9. A2575 Bestatin Aminopeptidase inhibitor
  10. A8621 Bestatin hydrochloride Inhibitor of aminopeptidase N (APN)/CD13 and aminopeptidase B.
  11. A4077 BIBR 953 (Dabigatran, Pradaxa) Thrombin inhibitor,potent,reversible and direct

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