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Proteases

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for  Proteases

product-structure
  1. Cat.No. Product Name Information
  2. A4410 Acetyl-Calpastatin (184-210) (human) Calpain I/II inhibitor
  3. A2573 AEBSF.HCl Serine protease inhibitor
  4. A4038 Alogliptin (SYR-322) DPP-4 inhibitor,potent and highly selective
  5. A3156 Alogliptin Benzoate DPP-4 inhibitor,selective and potent,antidiabetic drug
  6. B1037 Alvelestat NE inhibitor
  7. A8201 Amprenavir (agenerase) HIV-1 protease inhibitor
  8. A1038 Amyloid β-Peptide (10-20) (human) Initiates neurodegeneration in Alzheimer disease
  9. A3182 Anguizole Inhibitor of HCV replication
  10. A4341 Apixaban Factor Xa inhibitor
  11. A4016 Apoptosis Activator 2 Indoledione caspase activator, cell-permeable

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