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MAO

Monoamine oxidases (MAOs) are a family of enzymes that oxidize a number of biogenic amines through the production of hydrogen peroxide (H2O2). Two members of the MAO family have been identified and designated, MAO A and MAO B, which are encoded by two homologous genes comprising 15 exons with identical intro-exon organization and exhibit substrate-specificity. MAO A displays higher affinity towards serotonin, norepinephrine and dopamine; while MAO B displays higher affinity towards phenylethylamine and benzylamine.  Four highly conserved regions associated with the catalytic activity of mammalian MAO enzymes have been identified, including an ADP binding β-α-β unit, a putative substrate-binding domain, a FAD covalent attachment site, and a C terminus region predicted to form a transmembrane-associated α-helix.

product-structure
  1. Cat.No. Product Name Information
  2. C4137 Clorgyline (hydrochloride) MAO-A inhibitor
  3. B6153 Isatin endogenous monoamine oxidase inhibitor
  4. A4370 Moclobemide (Ro 111163) Reversible inhibitor of MAO-A
  5. C3106 Pargyline (hydrochloride) MAO inhibitor
  6. A4366 Rasagiline Mesylate Irreversible MAO-B inhibitor
  7. A4368 Safinamide Mesylate MAO-B inhibitor,potent,selective and reversible

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