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Sirtuin

Silent information regulator 2 (Sir2) proteins, also known as sirtuins, are a family of nicotine adenine dinucleotide (NAD) dependent protein deacetylases in organisms ranging from bacteria to humans that are characterized by the presence of a unique and highly conserved catalytic domain of approximately 260 amino acids. Sirtuins are divided into 5 classes, including Class I (subclasses Ia, Ib and Ic), Class II, Class III, Class IV (subclasses IVa and IVb) and Class U (Gram-positive bacteria specific). The catalytic domain of sirtuins is comprised of two bilobed globular domains, the large domain containing the NAD-binding pocket and the small domain binding the acetyl-lysine substrate.

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  1. Cat.No. Product Name Information
  2. C3552 4'-bromo-Resveratrol Sirt1 and Sirt3 inhibitor
  3. B7323 AGK 2 SIRT2 inhibitor, potent and selective
  4. C5709 AGK7 cell-permeable, selective inhibitor of SIRT2
  5. B4713 AK-7 selective and brain-permeable SIRT2 inhibitor
  6. A4181 EX 527 (SEN0014196) SIRT1 inhibitor
  7. B3272 Inauhzin SIRT1 inhibitor
  8. C5180 JFD00244 inhibitor of SIRT2
  9. C3888 JGB1741 SIRT1 inhibitor
  10. A4182 Resveratrol SIRT1 activator
  11. B7594 Salermide SIRT1 and SIRT2 inhibitor

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