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Sirtuin

Silent information regulator 2 (Sir2) proteins, also known as sirtuins, are a family of nicotine adenine dinucleotide (NAD) dependent protein deacetylases in organisms ranging from bacteria to humans that are characterized by the presence of a unique and highly conserved catalytic domain of approximately 260 amino acids. Sirtuins are divided into 5 classes, including Class I (subclasses Ia, Ib and Ic), Class II, Class III, Class IV (subclasses IVa and IVb) and Class U (Gram-positive bacteria specific). The catalytic domain of sirtuins is comprised of two bilobed globular domains, the large domain containing the NAD-binding pocket and the small domain binding the acetyl-lysine substrate.

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  1. Cat.No. Product Name Information
  2. C3552 4'-bromo-Resveratrol Sirt1 and Sirt3 inhibitor
  3. B7323 AGK 2 SIRT2 inhibitor, potent and selective
  4. C5709 AGK7 cell-permeable, selective inhibitor of SIRT2
  5. B4713 AK-7 selective and brain-permeable SIRT2 inhibitor
  6. A4181 EX 527 (SEN0014196) SIRT1 inhibitor
  7. B4912 EX-527 R-enantiomer SIRT1 inhibitor
  8. B4911 EX-527 S-enantiomer SIRT1 inhibitor
  9. B3272 Inauhzin SIRT1 inhibitor
  10. C5180 JFD00244 inhibitor of SIRT2
  11. C3888 JGB1741 SIRT1 inhibitor

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