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Protein Ser/Thr Phosphatases

Protein Ser/Thr phosphatases, belonging to the superfamily of protein phosphatases, are a diverse group of phosphatases that catalyze dephosphorylation and specifically remove phosphate groups from phosphorylated Ser and Thr residues within their substrates. Protein Ser/Thr phosphatases are comprised of two distinct families of phosphatases, including PPP phosphatases and PPM (or PP2C-related) phosphatases, which are coded by two unrelated gene families but share remarkably similar architecture of catalytic domains. PPP family was initially divided into two classes, type-I phosphatases (PP1) and type-2 phosphatases (PP2) consisting of PP2A, PP2B and PP2C isoforms. Novel protein phosphatases, such as PP4, PP5, PP6 and PP7, are also included in PPP family. PPM family is comprised of a number of Mg2+-dependent phosphatases encoded by different genes, which are structurally related to PP2C.

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  1. Cat.No. Product Name Information
  2. A4542 Alexidine dihydrochloride PTPMT1 inhibitor
  3. C4614 bpV(HOpic) (potassium salt, technical grade) protein tyrosine phosphatases (PTPs) inhibitor
  4. A4543 BVT 948 PTPs inhibitor,cell-permeable and non-competitve
  5. A4532 Calcineurin Autoinhibitory Peptide CaMKII inhibitor
  6. A4533 Calyculin A Protein phosphatase inhibitor
  7. C3898 Cantharidic Acid (sodium salt) PP1 and PP2A inhibitor
  8. B3274 CCT007093 PPM1D inhibitor
  9. A4534 Ceramide Protein phosphatase and CAPP modulator
  10. A8223 CID 2011756 PKD inhibitor
  11. A4535 DL-AP3 Glutamate receptor antagonist and HPSP inhibitor

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