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Histone Demethylases

Histone demethylases are a diverse group of enzymes catalyzing a process to reverse histone methylation, in which methyl (CH3-) groups are removed from instead of being transferred to histone.  So far, two evolutionarily conserved histone demethylase families have been identified, including LSD demethylases and JMJC demethylases. LSD1 and LSD2 are two well-established members of LSD demethylase family, which catalyze demethylation through a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction. LSD1 has been found to demethylate H3K4mel, H3K4me2, H3K9me1, H3K9me2 and a few non-histone targets; while LSD2 has been found to demethylate only H3K4me1 and H3K4me2. Members of JMJC demethylase family is characterized by containing the catalytic JMJC domain, which demethylate substrates, including H3K4, H3K9, H3K27, H3K36 and H4K20, through a Fe(II)- and α-ketogutarate-dependent dioxygenase reaction.

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  1. Cat.No. Product Name Information
  2. B5972 2,4-Pyridinedicarboxylic Acid Histone LSD inhibitor
  3. A8176 Apicidin Potent HDAC inhibitor
  4. B6084 AS8351 histone demethylase inhibitor
  5. C5162 Bizine LSD1 inhibitor
  6. B1263 CBB1007 LSD1 inhibitor,potent and selective
  7. B7811 CPI-455 KDM5 inhibitor
  8. A4191 GSK J1 H3K27 demethylase JMJD3 inhibitor
  9. B5685 GSK J2 inactive control of GSK J1, JMJD3 (KDM6B) and UTX (KDM6A) inhibitor
  10. B5959 GSK J4 free base histone demethylase JMJD3/UTX inhibitor
  11. A4190 GSK J4 HCl Inhibitor of H3K27 demethylase JMJD3,potent and cell-permeable

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