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Histone Acetyltransferases

Histone acetyltransferases (HATs) are a diverse group of enzymes catalyzing a posttranslational modification of acetylation in which the acetyl group from the acetyl-CoA cofactor is transferred to the Nζ nitrogen of the target lysine side chain within histones. Based on the sequence divergence within the HAT domain, HATs is classified into at least five distinct families, including HAT1 family, Gcn5/PCAF family, MYST family, p300/CBP family and Rtt109 family. Despite the sequence divergence, a structurally conserved core region has been identified within each of the protein families, which contains a three-stranded β-sheet with a α—helix corresponding to the A and D regions of the Gcn5-related N-acetyltransferases (GNAT) proteins.

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  1. Cat.No. Product Name Information
  2. B1577 C646 C646, a pyrazolone-containing small molecule, is a cell-permeable histone acetyltransferase (HAT) inhibitor that competitively and selectively inhibits the HAT activity of p300, a transcriptional co-activator involved in a variety of gene regulatory pathways and protein acetylation events, with the inhibition constant Ki value of 400 nM and the half maximal inhibition concentration IC50 value of 1.6 μM .
  3. C5773 CTPB
  4. C5000 HAT Inhibitor II
  5. C3209 Butyrolactone 3
  6. C3208 CPTH2 (hydrochloride)
  7. A8712 MCB-613 4-ethyl-2,6-bis-pyridin-3-ylmethylene-cyclohexanone, is a novel and potent stimulator of p160 steroid receptor coactivators (SRCs).
  8. B4946 Garcinol
  9. B4945 IWP 12
  10. B4887 Remodelin Remodelin is a potent inhibitor of NAT10 [1]
  11. B7739 L002 New Product

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