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Histone Acetyltransferases

Histone acetyltransferases (HATs) are a diverse group of enzymes catalyzing a posttranslational modification of acetylation in which the acetyl group from the acetyl-CoA cofactor is transferred to the Nζ nitrogen of the target lysine side chain within histones. Based on the sequence divergence within the HAT domain, HATs is classified into at least five distinct families, including HAT1 family, Gcn5/PCAF family, MYST family, p300/CBP family and Rtt109 family. Despite the sequence divergence, a structurally conserved core region has been identified within each of the protein families, which contains a three-stranded β-sheet with a α—helix corresponding to the A and D regions of the Gcn5-related N-acetyltransferases (GNAT) proteins.

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  1. Cat.No. Product Name Information
  2. B7679 (R)-(+)-Etomoxir sodium salt carnitine palmitoyltransferase I (CPT1) inhibitor
  3. C3209 Butyrolactone 3 histone acetyltransferase Gcn5 inhibitor
  4. B1577 C646 HAT p300-CBP inhibitor,cell-permeable
  5. B6987 CI 976 acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitor
  6. C3208 CPTH2 (hydrochloride) inhibitor of HAT activity of Gcn5
  7. C5773 CTPB selective activator of the histone acetyltransferase (HAT) p300
  8. B1602 Donepezil HCl AChE inhibitor
  9. B4946 Garcinol Inhibitor of PCAF and p300 histone acetyltransferase (HAT) activity
  10. C5000 HAT Inhibitor II inhibitor of the histone acetyltransferase p300
  11. B4945 IWP 12 Potent inhibitor of Porcupine (PORCN)

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