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TNF-α

Tumor necrosis factor alpha (TNF-α), belongs to the superfamily of TNF/TNFR cytokine superfamily, is a type II transmembrane protein (mTNF) with an intracellular N terminus that is produced as 26 kDa membrane-bound cytokine comprised of 233 amino acids. TNF-α also exists as a soluble cytokine (sTNF), which is a non-covalently bound 17 kDa trimer (157 amino acids with a 76 amino acid presequence) resulted from the cleavage of mTNF by TNF-α converting enzyme (TACE). Two distinct and highly affinitive receptors of TNF-α have been identified, including TNFR55 (a 55 kDa receptor) and TNFR75 (a 75 kDa receptor), through which multiple activities of TNF-α are mediated. TNF-α has been found to be involved in maintenance and homeostasis of the immune system, inflammation and host defence as well as a variety of pathological processes.

Antibodies

  1. Cat.No. Product Name Information
  2. T1302 TNF-α Antibody Polyclonal TNF-α antibody, reacts with TNF-α and precursor protein
  3. T1301 TNF-α Antibody (43S9) Monoclonal TNF-α antibody, reacts with total TNF-α protein
  4. T1300 TNF-α Antibody (55D6) Monoclonal TNF-α antibody, reacts with total TNF-α protein
  5. T1299 TNF-R1 Antibody Monoclonal TNF-R1 antibody, reacts with total TNF-R1 protein

Biochemicals

  1. Cat.No. Product Name Information
  2. A4211 Lenalidomide (CC-5013) Top Seller Antitumor compound, inhibits angiogenesis
  3. A4216 Thalidomide sedative drug,immunomodulatory agent
  4. A4213 Necrostatin-1 specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis
  5. A4212 Pomalidomide (CC-4047) Top Seller Antitumor compound, inhibits angiogenesis
  6. A2604 Celastrol Antioxidant, anti-inflammatory and immunosuppressive agent.
  7. A3547 Lenalidomide hydrochloride Lenalidomideis a derivative of thalidomide introduced in 2004. Lenalidomide (Revlimid, CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM.
  8. A3652 Necrostatin 2 potent in vitro necroptosis inhibitors
  9. A3960 Necrostatin 2 racemate potent in vitro necroptosis inhibitors
  10. B1188 Lenalidomide hemihydrate New Product, Cas No.:847871-99-2, Please Inquiry
  11. A3961 Necrostatin 2 S enantiomer potent in vitro necroptosis inhibitors