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TNF-α

Tumor necrosis factor alpha (TNF-α), belongs to the superfamily of TNF/TNFR cytokine superfamily, is a type II transmembrane protein (mTNF) with an intracellular N terminus that is produced as 26 kDa membrane-bound cytokine comprised of 233 amino acids. TNF-α also exists as a soluble cytokine (sTNF), which is a non-covalently bound 17 kDa trimer (157 amino acids with a 76 amino acid presequence) resulted from the cleavage of mTNF by TNF-α converting enzyme (TACE). Two distinct and highly affinitive receptors of TNF-α have been identified, including TNFR55 (a 55 kDa receptor) and TNFR75 (a 75 kDa receptor), through which multiple activities of TNF-α are mediated. TNF-α has been found to be involved in maintenance and homeostasis of the immune system, inflammation and host defence as well as a variety of pathological processes.

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Biochemicals

  1. Cat.No. Product Name Information
  2. A4211 Lenalidomide (CC-5013) Top Seller Antineoplastic agent,inhibits angiogenesis
  3. A4212 Pomalidomide (CC-4047) Top Seller Immunomodulator,antumor/anti-angiogenic
  4. A4213 Necrostatin-1 RIP1 inhibitor
  5. A2604 Celastrol Antioxidant, anti-inflammatory and immunosuppressive agent
  6. A3547 Lenalidomide hydrochloride TNF-α secretion inhibitor
  7. A3652 Necrostatin 2 In vitro necroptosis inhibitor
  8. A3960 Necrostatin 2 racemate In vitro necroptosis inhibitor
  9. B1188 Lenalidomide hemihydrate Lenalidomide (Revlimid, CC-5013) is a TNF-α secretion inhibitor with IC50 of 13 nM.
  10. A3961 Necrostatin 2 S enantiomer In vitro necroptosis inhibitor
  11. B3921 Roquinimex
  12. B6090 Bioymifi