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TNF-α

Tumor necrosis factor alpha (TNF-α), belongs to the superfamily of TNF/TNFR cytokine superfamily, is a type II transmembrane protein (mTNF) with an intracellular N terminus that is produced as 26 kDa membrane-bound cytokine comprised of 233 amino acids. TNF-α also exists as a soluble cytokine (sTNF), which is a non-covalently bound 17 kDa trimer (157 amino acids with a 76 amino acid presequence) resulted from the cleavage of mTNF by TNF-α converting enzyme (TACE). Two distinct and highly affinitive receptors of TNF-α have been identified, including TNFR55 (a 55 kDa receptor) and TNFR75 (a 75 kDa receptor), through which multiple activities of TNF-α are mediated. TNF-α has been found to be involved in maintenance and homeostasis of the immune system, inflammation and host defence as well as a variety of pathological processes.

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  1. Cat.No. Product Name Information
  2. A2604 Celastrol Antioxidant, anti-inflammatory and immunosuppressive agent
  3. B6109 CPI-1189 necrosis factor (TNF) alpha inhibitor
  4. B6194 GSK481 RIP1(Receptor Interacting Protein Kinase 1) inhibitor
  5. A4211 Lenalidomide (CC-5013) Antineoplastic agent,inhibits angiogenesis
  6. B1188 Lenalidomide hemihydrate TNF-α secretion inhibitor
  7. A3547 Lenalidomide hydrochloride TNF-α secretion inhibitor
  8. C4832 Maslinic Acid inhibitor of NO, H2O2 , IL-6 and TNF-α
  9. A3652 Necrostatin 2 In vitro necroptosis inhibitor
  10. A4213 Necrostatin-1 RIP1 inhibitor
  11. A4212 Pomalidomide (CC-4047) Immunomodulator,antumor/anti-angiogenic

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