p53
The p53 tumor suppressor is a 53 kDa nuclear phosphoprotein of 393 amino acids that is encoded by the TP53 gene (20 kb with 11 exons and 10 introns) and characterized by the presence of several structural and functional domains, including a N-terminus, a central core domain, a C-terminal region, a strongly basic carboxyl-terminal regulatory domain, a nuclear localization signal sequence and three nuclear export signal sequence. The p53 is considered as a major “guardian of genome” for its activities in a wide range of cellular events, including cell-cycle regulation, induction of apoptosis, gene amplification, DNA recombination, chromosomal segregation and cellular senescence.
- Cat.No. Product Name Information
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A8804
AMG232
p53-MDM2 inhibitor, novel
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C3171
CBL0137
curaxin that activates p53 and inhibits NF-κB
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C3192
CBL0137 (hydrochloride)
curaxin that activates p53 and inhibits NF-κB
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C4483
COTI-2
activates mutant forms of p53
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A4476
CP 31398 dihydrochloride
p53 stabilizer
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A4477
Cyclic Pifithrin-α hydrobromide
P53 inhibitor
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C4840
GN25
p53-Snail binding Inhibitor
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A4478
HLI 373
Hdm2 ubiquitin ligase (E3) inhibitor
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A4204
JNJ-26854165 (Serdemetan)
P53 activator, blocking Mdm2-p53 interaction
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A4479
MIRA-1
Restorer of wild-type p53 conformation/cellular function