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p53

The p53 tumor suppressor is a 53 kDa nuclear phosphoprotein of 393 amino acids that is encoded by the TP53 gene (20 kb with 11 exons and 10 introns) and characterized by the presence of several structural and functional domains, including a N-terminus, a central core domain, a C-terminal region, a strongly basic carboxyl-terminal regulatory domain, a nuclear localization signal sequence and three nuclear export signal sequence. The p53 is considered as a major “guardian of genome” for its activities in a wide range of cellular events, including cell-cycle regulation, induction of apoptosis, gene amplification, DNA recombination, chromosomal segregation and cellular senescence.

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Biochemicals

  1. Cat.No. Product Name Information
  2. A4228 Nutlin-3 Top Seller MDM2 antagonist,inhibits MDM2-p53 interaction
  3. A4206 Pifithrin-α (PFTα) p53 inhibitor
  4. B6045 NSC59984 Restores the p53 signaling pathway
  5. A9903 p53/MDM2 Set I
  6. A8567 Tenovin-3 Top Seller Tenovin-3
  7. A4486 SJ 172550 MDMX inhibitor
  8. A3671 Nutlin-3a chiral Top Seller MDM2 inhibitor, antiproliferative and antiproapoptotic
  9. A4484 PRIMA-1MET Top Seller Restore mutant p53 activity, induce BAX and PUMA
  10. A4483 PRIMA-1 Top Seller BAX inhibitor
  11. A4203 Tenovin-1 Top Seller SIRT2 inhibitor, activates p53
  12. A4204 JNJ-26854165 (Serdemetan) Top Seller P53 activator, blocking Mdm2-p53 interaction
  13. A4482 Pifithrin-μ Inhibitor of p53 binding and anti-apoptotic
  14. A4477 Cyclic Pifithrin-α hydrobromide P53 inhibitor
  15. A3762 RG7112 MDM2 inhibitor, first clinical
  16. A4202 RITA (NSC 652287) Mdm2-p53 interaction and p53 ubiquitination blocking
  17. A3763 RG7388 MDM2 antagonist, oral, selective
  18. A3693 p53 and MDM2 proteins-interaction-inhibitor chiral P53 and MDM2 proteins-interaction-inhibitor
  19. A3694 p53 and MDM2 proteins-interaction-inhibitor racemic P53 and MDM2 proteins-interaction-inhibitor
  20. A4456 Plumbagin Anticancer agent
  21. A4476 CP 31398 dihydrochloride p53 stabilizer
  22. A8804 AMG232 p53-MDM2 inhibitor, novel
  23. A4478 HLI 373 Hdm2 ubiquitin ligase (E3) inhibitor
  24. A4455 Piperlongumine Inducer of cell-death
  25. A4208 NSC 319726 Reactivator of mutant p53
  26. A4479 MIRA-1 Restorer of wild-type p53 conformation/cellular function
  27. A4480 NSC 146109 hydrochloride Antitumor agent,p53-dependent transcription activator
  28. A4481 PhiKan 083 p53 stabilizer
  29. A4485 RETRA hydrochloride Antitumor agent
  30. A4487 WR 1065 P53/p21waf-1/MDM2 activator
  31. B4677 NVP-CGM097

Bioactive Peptides

  1. Cat.No. Product Name Information
  2. A1094 tumor protein p53 binding protein fragment [Homo sapiens]/[Mus musculus] P53 binding protein fragment
  3. A1083 p53 tumor suppressor fragment Regulates cell cycle