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KEAP1-Nrf2

The KEAP1-Nrf2 pathway is the major regulator of cytoprotective responses to chemical and/or oxidative stresses caused by reactive oxygen species (ROS) and electrophiles. Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that binds together with small Maf proteins to the antioxidant response element (ARE) in the regulatory regions of cellular defense enzyme genes leading to the activation of a wide rang of cell defense processes; while KEAP1 (Kelch ECH associating protein 1), a negative repressor of Nrf2, is an adaptor protein for a Cul3-based ubiqutitin E3 ligase that binds to Nrf2 and promotes its degradation by the ubiquitin proteasome pathway.

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  1. Cat.No. Product Name Information
  2. C3234 2-HBA indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway.
  3. N2172 5,7-dihydroxychromone Nrf2/ARE signal activator and PPARγ agonist
  4. A3220 Bardoxolone Once-a-day treatment for CKD
  5. C4354 CDDO-TFEA Nrf2 activator
  6. A3335 Curcumin Tyrosinase inhibitor
  7. B1931 Dimethyl Fumarate nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator
  8. N2285 Dimethylfraxetin Extracted from Fraxinus chinensis;Store the product in sealed, cool and dry condition.
  9. C5715 NK 252 Nrf2 activator
  10. B3576 Omaveloxolone (RTA-408) Nrf2 activator
  11. C4733 Sulforaphane inducer of chemopreventative enzymes via Keap1-Nrf2 signaling

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