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Caspase

Caspases (cysteine-dependent aspartate specific ptotease) are a family of cysteine proteases that play an essential role in cell apoptosis. Caspases contain a conserved QACXG pentapeptide active site motif and are characterized by specificity for aspartic acid in the P1 position. The synthesis of caspases involves the activation of inactive proenzymes, which contain an N-terminal peptide (prodomain) together with two subunits (one small and one large), following cleavage at specific aspartate cleavage sites. Caspases can be classified into three subfamilies, due to phylogenetic analysis, including an ICE subfamily (caspases-1, -4 and -5), a CED-3/CPP32 subfamily (caspases-3, -6, -7, -8, -9 and -10) and an ICH-1/Nedd2 subfamily (caspase-2).

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  1. Cat.No. Product Name Information
  2. A8321 Cisplatin Inhibits DNA synthesis,chemotherapy drug
  3. A3424 Gambogic Acid Caspase activator and apoptosis inducer
  4. A4417 Ivachtin Caspase-3 inhibitor
  5. C4468 NS3694 inhibits apoptosome formation and caspase activation
  6. A8177 PAC-1 Procaspase-3 activator
  7. A4420 PETCM Caspase-3 activator
  8. A8165 Q-VD(OMe)-OPh Pan-caspase inhibitor
  9. A1901 Q-VD-OPh hydrate Cell-permeable, irreversible pan-caspase inhibitor
  10. C5667 Se-Aspirin nonsteroidal anti-inflammatory drug
  11. A8238 VX-765 Caspase-1 inhibitor,potent and selective

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