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Caspase-1, human recombinant proteinase

Catalog No.
E1001
Caspase-1, cysteine proteinase, expressed in E.Coli.
Grouped product items
SizePriceStock Qty
25 units
$233.00
Ship with 10-15 days
100 units
$410.00
Ship with 10-15 days

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Caspase-1 (also know as Interleukin-1β-Converting Enzyme) is a prototypical member of the caspase-family of cysteine proteases. Caspase-1 exists in cells as an inactive 45 kDa proenzyme, which is matured by proteolysis to yield large (20 kD) and small (10 kD) subunits. The active caspase-1 is a heterotetramer consisting of two large and two small subunits. To date the mechanism of regulation of caspase-1 activation is complex and poorly understood. The recombinant active human caspase-1 was expressed in E. coli. The active caspase-1 preferentially cleaves caspase-1 substrates (YVAD-AFC or YVAD-pNA) and is routinely tested for its ability to enzymatically cleave Ac-YVAD-pNA or Ac-YVAD-AFC. The recombinant human Caspase-1 has an N-term His-tag and corresponds to amino acids 120-404 of Caspase-1. Active caspase-1 is useful in studying enzyme regulation, determining target substrates, screening caspase inhibitors, or as a positive control in caspase activity assays. We recommend using 1 unit/assay for analyzing caspase activity.

Description

Gene ID: 834 Accession #: NP_150634.1
Alternate Names:Active Human Caspase-1, Active Caspase-1, Caspase-1 Enzyme, Recombinant caspase-1, human caspase-1, human caspases, active caspases.
Source: Escherichia Coli. M.Wt: large (20 kD) and small (10 kD) subunits
Appearance: Semi-Dry powder Storage: Store at -70℃
Formulation:Lyophilized powder
Solubility:Reconstitute to 1 unit per µl in PBS containing 15% glycerol.
Shipping Condition: gel pack. Handling: Centrifuge the vial prior to opening.
Usage:For Research Use Only! Not to be used in humans.

Quality Control

Quality Control & DataSheet

View current batch:
    Purity: N/A.
    Endotoxin Level: N/A