Endocrinology and Hormones
There are three types of hormones based on their chemical composition: Amines (e.g. dopamine, adrenalin and noradrenalin); Steroids (e.g. estrogen, testosterone and glucocorticoids); Peptides (e.g. the peptide hormones insulin, ghrelin and vasopressin). Peptide hormones produced by secretory nervous tissue are known as neuropeptides. For example, thyroid hormone plays important parts in development, homeostasis and metabolism, while cortisol is essential for growth, nutrient supply and immune function. Moreover, the regulation of blood glucose involves several pancreatic peptide insulin and its counter regulatory hormone, glucagon, as well as cortisol, growth hormone and epinephrine.
Dysregulations in endocrine system are implicated in diseases such as Acromegaly, Cushing Syndrome, Diabetes, Dwarfism, Graves Disease, Hermaphroditism, Delayed and Precocious Puberty and Thyroid Diseases.
- A5143 FinasterideSummary: Inhibitor of Type II 5α-reductase
- A1296 ExemestaneSummary: Steroidal aromatase inhibitor,selective and irreversible
- A1307 LetrozoleTarget: AromatasesSummary: Non-steroidal aromatase inhibitor
- A1425 Losartan Potassium (DuP 753)Summary: Angiotensin AT1 receptor antagonist
- A2986 ADL5859 HClSummary: δ-opioid receptor agonist,selective
- A2150 AndarineTarget: Androgen ReceptorsSummary: Androgen receptor agonist
- A5932 CandesartanSummary: Angiotensin II receptor 1 (AT1) antagonist
- A8019 Perindopril ErbumineTarget: Angiotensin-Converting Enzymes (ACEs)Summary: ACE inhibitor
- A1372 AZD3514Summary: Androgen receptor downregulator
- A8364 ARN-5092 CitationTarget: Androgen ReceptorSummary: Androgen receptor inhibitor