Endocrinology and Hormones
There are three types of hormones based on their chemical composition: Amines (e.g. dopamine, adrenalin and noradrenalin); Steroids (e.g. estrogen, testosterone and glucocorticoids); Peptides (e.g. the peptide hormones insulin, ghrelin and vasopressin). Peptide hormones produced by secretory nervous tissue are known as neuropeptides. For example, thyroid hormone plays important parts in development, homeostasis and metabolism, while cortisol is essential for growth, nutrient supply and immune function. Moreover, the regulation of blood glucose involves several pancreatic peptide insulin and its counter regulatory hormone, glucagon, as well as cortisol, growth hormone and epinephrine.
Dysregulations in endocrine system are implicated in diseases such as Acromegaly, Cushing Syndrome, Diabetes, Dwarfism, Graves Disease, Hermaphroditism, Delayed and Precocious Puberty and Thyroid Diseases.
- B5455 G-14 CitationTarget: GPR30Summary: GPR30 agonist, potent and selective
- B5469 G-153 CitationTarget: GPR30Summary: GPER receptor antagonist
- B5707 G-36Summary: G-36 is a selective GPER antagonist
- B4871 OspemifeneSummary: non-hormonal selective estrogen receptor modulator (SERM)
- B5912 ChlorotrianiseneSummary: Estrogen agonist
- A8452 ODM-201Target: Androgen ReceptorsSummary: new-generation androgen receptor inhibitor
- B6041 EPI-001Summary: AR antagonist
- A3003 MDV3100 (Enzalutamide)12 CitationTarget: Androgen ReceptorsSummary: Androgen receptor antagonist
- A4078 CaptoprilSummary: ACE inhibitor
- A4326 TAK-700 (Orteronel)2 CitationTarget: human lyaseSummary: Human 17,20-lyase inhibitor