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Signaling Pathways

Items 61-70 of 498

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  1. Dovitinib (TKI-258, CHIR-258)
    A2168 Dovitinib (TKI-258, CHIR-258)
     2 Citation
    Target: FLT3|VEGFR|PDGFR|c-Kit|FGFR
    Summary: Multitargeted RTK inhibitor
      insoluble in H2O; insoluble in EtOH; ≥36.35 mg/mL
  2. 17-DMAG (Alvespimycin) HCl
    A2213 17-DMAG (Alvespimycin) HCl
     1 Citation
    Target: HSP90
    Summary: Hsp90 inhibitor
      ≥26.2 mg/mL
  3. Cediranib (AZD217)
    A1882 Cediranib (AZD217)
    Target: VEGFR
    Summary: VEGFR inhibitor receptor,highly potent
      ≥22.52 mg/mL
  4. CP-724714
    A2412 CP-724714
    Target: VEGFR|PDGFR|Bcr-Abl|Src|EGFR|c-MET|Insulin Receptors|IRG-1R
    Summary: HER2 inhibitor,potent and selective
      ≥23.5 mg/mL
  5. Tivozanib (AV-951)
    A2251 Tivozanib (AV-951)
    Target: VEGFR
    Summary: VEGFR inhibitor,potent and selective
      ≥22.75 mg/mL
  6. Epothilone B (EPO906, Patupilone)
    A1630 Epothilone B (EPO906, Patupilone)
    Target: Microtubules/Tubulins
    Summary: Microtubule stabilizing macrolide
      ≥25.4 mg/mL
  7. Lenvatinib (E7080)
    A2174 Lenvatinib (E7080)
    Target: VEGFR|PDGFR|RET
    Summary: VEGFR inhibitor
      ≥21.35 mg/mL
  8. Rigosertib sodium salt
    A1404 Rigosertib sodium salt
     1 Citation
    Target: PLK
    Summary: Plk1 inhibitor
      ≥23.65 mg/mL
  9. WZ8040
    A1393 WZ8040
    Target: EGFR
    Summary: EGFR T790M inhibitor,irreversible amd potent
      ≥24.05 mg/mL
  10. MGCD-265
    A5057 MGCD-265
    Target: VEGFR|c-MET
    Summary: Met/Flt/Flk/Ron/Tie-2 inhibitor
      ≥25.9 mg/mL

Items 61-70 of 498

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  1. Proteases31item
  2. Apoptosis33item
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  4. Metabolism30item
  5. MAPK Signaling25item
  6. Tyrosine Kinase84item
  7. DNA Damage/DNA Repair53item
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Target
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  38. Bromodomain-containing proteins(BRDs)1 item
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  50. FGFR8item
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  55. Deubiquitinating enzymes (DUBs)3item
  56. PP11 item
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  78. Syk4item
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  115. Calcium chelator1 item
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  120. Sphingosine kinases (SphKs)1 item
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  129. D2 Receptors2item
  130. D3 Receptors1 item
  131. Valosin-containing protein (VCP)1 item
  132. MELK1 item
  133. Insulin-like growth factors (IGFs)1 item
  134. Integrin-ligand interactions1 item
  135. CSF1R1 item
  136. Bromodomain and Extra-Terminal motif (BET)1 item
  137. MK22item
  138. 5-HT3 Receptors1 item
  139. Angiotensin-Converting Enzymes (ACEs)1 item
  140. Tie-23item
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  142. p70 S6K1 item
  143. Autophagy3item
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  152. CK21 item
  153. HIPK21 item
  154. HIPK31 item
  155. G-quadruplexes1 item
  156. PRAK1 item
  157. MAPKAP-K21 item
  158. 20S proteasomal chymotrypsin1 item
  159. Geranylgeranyltransferase I1 item
  160. Farnesyltransferase1 item
  161. Nampt2item
  162. eIF4F1 item
  163. Cdc421 item
  164. P2X Receptors1 item
  165. Glutaminases1 item
  166. Carbonic Anhydrases1 item
  167. Ron1 item
  168. BLM1 item
  169. Aldehyde Dehydrogenases1 item
  170. Synthases/Synthetases3item
  171. MAGL1 item
  172. Histamine H1 Receptors1 item
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  174. P1101 item
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  176. Inositol-requiring enzyme 1 (IRE1)1 item
  177. iNOS1 item
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  179. RNA Polymerases1 item
  180. Norepinephrine transporter1 item
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  188. Insulin Receptors1 item
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  190. cAMP1 item
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  193. Cdc71 item
  194. CMV1 item
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  196. Catechol O-Methyltransferase (COMT)1 item
  197. fibrinolysis1 item
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  199. O6-methylguanine-DNA-methyl-transferase (MGMT)1 item
  200. Flk-11 item
  201. Papains1 item
  202. RNA synthesis1 item
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  204. NAE2item
  205. Ubiquitin-activating Enzyme E11 item
  206. SUMOylation1 item
  207. Cytidine deaminases1 item
  208. angiogenesis1 item
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  213. nuclear export1 item
  214. CRM11 item
  215. AXL1 item
  216. human lyase1 item
  217. Ub-conjugating enzyme (E2) complex1 item
  218. MCL11 item
  219. Bcl-w1 item
  220. tropomyosin receptor kinase1 item
  221. LSD1 item
  222. SK1 item
  223. IDO1 item
  224. Substance P/NK1 Receptor1 item
Reported Experiments
  1. Animal Experiments453item
  2. Cell Experiments272item