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Signaling Pathways

Items 21-30 of 444

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  1. PF-04929113 (SNX-5422)
    A4065 PF-04929113 (SNX-5422)
    Target: HSP90
    Summary: Hsp90 inhibitor,potent and selective
      ≥23.85 mg/mL
  2. Radicicol
    A4067 Radicicol
    Summary: ATPase/kinase inhibitor
      Soluble in ethanol
  3. SNX-2112
    A4068 SNX-2112
     1 Citation
    Summary: Hsp90 inhibitor,ATP-competitve,potent and selective
      ≥23.05 mg/mL
  4. Tipifarnib (Zarnestra)
    A4227 Tipifarnib (Zarnestra)
    Summary: Farnesyltransferase inhibitor,potent and specific
      insoluble in H2O; ≥8.16 mg/mL
  5. Abiraterone acetate
    A8202 Abiraterone acetate
    Target: Cytochrome P450 (CYP450)
    Summary: Cytochrome p450 17a1 inhibitor
      insoluble in H2O; ≥11.22 mg/mL
  6. Abiraterone
    A4240 Abiraterone
     1 Citation
    Summary: Potent CYP17 inhibitor
      insoluble in EtOH; insoluble in H2O; ≥5.57 mg/mL
  7. GW9662
    A4300 GW9662
     1 Citation
    Summary: PPARγ antagonist
      insoluble in H2O; ≥13.75 mg/mL
  8. T0070907
    A4301 T0070907
    Summary: Human PPARγ antagonist,potent and selective
      ≥27.8 mg/mL
  9. Rosiglitazone maleate
    A4302 Rosiglitazone maleate
    Target: Insulin and Insulin-like Receptors
    Summary: PPARγ agonist,high-affinity and selective,potent insulin sensitizer
      ≥23.7 mg/mL
  10. GSK3787
    A4303 GSK3787
    Summary: PPARβ/δ antagonist,novel and irreversible
      insoluble in H2O; ≥15.8 mg/mL

Items 21-30 of 444

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  1. PPAR49item
  2. 5-alpha Reductase3item
  3. 5-Lipoxygenase11item
  4. Adenosine Deaminase3item
  5. Aminopeptidase1 item
  6. C14ɑ demethylase2item
  7. Carbonic Anhydrase8item
  8. CETP4item
  9. Cholesterol absorption1 item
  10. CPT12item
  11. CYP3A/CYP45017item
  12. Dehydrogenase35item
  13. DHFR6item
  14. DGAT6item
  15. Dopamine β-hydroxylase6item
  16. Enolase1 item
  17. FAAH19item
  18. Factor Xa3item
  19. Ferroptosis3item
  20. Folate Analogue2item
  21. Glucokinase1 item
  22. HLE1 item
  23. HMG-CoA Reductase13item
  24. HSP24item
  25. IDO7item
  26. KRAS-PDEδ3item
  27. Lipid Metabolism14item
  28. MAO6item
  29. Neuronal Metabolism7item
  30. Oxidative Phosphorylation3item
  31. P45017item
  32. PDE55item
  33. Phospholipase32item
  34. Procollagen C Proteinase1 item
  35. Saccharometabolism1 item
  36. SCD3item
  37. SGLT7item
  38. TPH4item
  39. Transferase21item
  40. Transaminase1 item
  41. monooxygenase1 item
  42. PKM21 item
  43. aldehyde dehydrogenase1 item
  44. Squalene synthase1 item
  45. Hydrolase10item
  46. ornithine decarboxylase1 item
  47. Amino acid metabolism3item
  48. phosphatases5item
  49. Pyruvate kinase1 item
  50. Others4item
  51. MGL1 item
  52. Galactosidase1 item
  53. 12-Lipoxygenase1 item
  54. Dehydrogenase inhibitors1 item
  55. Lipase inhibitor1 item
  56. Dehydrogenase inhibitor1 item
  57. Decarboxylase inhibitor1 item
Specificity
  1. Selective80item
  2. Non-Selective1 item
Reversibility
  1. Reversible1 item
  2. Irreversible5item
Target
  1. Acyl coenzyme A: cholesterol acyltransferases1 item
  2. Factor Xa1 item
  3. Phosphodiesterases (PDEs)17item
  4. Thymidylate Synthase1 item
  5. 3-phosphoglycerate dehydrogenase1 item
  6. Kynurenine-3-monooxygenase1 item
  7. RARs1 item
  8. Aminopeptidases1 item
  9. Stearoyl-CoA 9-desaturase (SCD-1)2item
  10. HSP909item
  11. Cytochrome P450 (CYP450)7item
  12. Ferroptosis1 item
  13. HMG-CoA Reductases6item
  14. SGLT1 item
  15. DGAT2item
  16. Insulin and Insulin-like Receptors1 item
  17. Pyruvate dehydrogenases (PDH)1 item
  18. CETP2item
  19. Lactate Dehydrogenases (LDH)3item
  20. Fatty-acid-binding proteins (FABPs)1 item
  21. Folate Analogue1 item
  22. IDH21 item
  23. Nampt1 item
  24. Carbonic Anhydrases3item
  25. Aldehyde Dehydrogenases2item
  26. Phospholipases1 item
  27. Inward Rectifier Potassium (Kir) Channels1 item
  28. Catechol O-Methyltransferase (COMT)1 item
  29. Hydroxylases1 item
  30. FPTase1 item
  31. Tryptophan hydroxylases (TPH)2item
  32. sodium channel1 item
  33. PPAR5item
  34. Ftase1 item
  35. PC-PLC1 item
  36. GK1 item
  37. HMGCR1 item
  38. adrenergic receptor1 item
  39. sterol demethylase1 item
  40. GAPDH1 item
  41. complex I of the mitochondrial electron transport chain1 item
  42. potassium channel1 item
  43. calcium channel1 item
  44. FAAH1 item
  45. carnitine reabsorption1 item
  46. 5-alpha Reductases1 item
  47. DHFR1 item
  48. GARFT1 item
  49. glutathione peroxidase 41 item
  50. S-adenosylhomocysteine hydrolase1 item
  51. IDO1 item
  52. Tph1 item
  53. epoxide hydrolase1 item
  54. Cholesterol absorption1 item
  55. Glycogen Phosphorylases1 item
Reported Experiments
  1. Animal Experiments114item
  2. Cell Experiments93item
Related Disease
  1. Acne1 item
  2. Acute Kidney Injury1 item
  3. Acute Myelogenous Leukemia1 item
  4. Acute Myeloid Leukemia2item
  5. Bladder Cancer1 item
  6. Bladder Carcinoma1 item
  7. Brain Injuries Studies1 item
  8. Breast Cancer10item
  9. Cancer37item
  10. Cervical Cancer1 item
  11. Chronic Lymphocytic Leukemia1 item
  12. Cocaine-Related Disorders2item
  13. Colon Cancer1 item
  14. Diabetes4item
  15. Dyslipidemia1 item
  16. Epilepsy2item
  17. Erectile Dysfunction4item
  18. Fungi1 item
  19. Glioblastoma1 item
  20. Glioma1 item
  21. Hepatic Cancer1 item
  22. HIV Infections1 item
  23. Hypercholesterolemia3item
  24. Inflammation1 item
  25. Inflammatory Diseases2item
  26. Kidney Injury Studies1 item
  27. Leukemia2item
  28. Lung Cancer5item
  29. Lymphoma3item
  30. Melanoma9item
  31. Multiple Myeloma3item
  32. Neuroblastoma3item
  33. Neurocognitive Disorders1 item
  34. Non-small Cell Lung Cancer2item
  35. Obsessive-Compulsive Disorder1 item
  36. Osteoporosis1 item
  37. Pancreatic Cancer2item
  38. Pancreatic Carcinoma1 item
  39. Prostate Cancer7item
  40. Psoriasis3item
  41. Psoriasis Vulgaris1 item
  42. Pulmonary Arterial Hypertension1 item
  43. Rheumatoid Arthritis2item
  44. Schizophrenia2item
  45. Type 2 Diabetes5item