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Signaling Pathways

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  1. Cobicistat (GS-9350)
    A4313 Cobicistat (GS-9350)
    Target: Cytochrome P450 (CYP450)
    Summary: Selective CYP3A inhibitor
      insoluble in H2O; ≥150.9 mg/mL
  2. Voriconazole
    A4320 Voriconazole
    Summary: CYP51 inhibitor
      ≥34.9 mg/mL
  3. Clarithromycin
    A4322 Clarithromycin
    Target: Cytochrome P450 (CYP450)
    Summary: CYP3A inhibitor, potent
      ≥31.2 mg/mL
  4. Dronedarone
    A3374 Dronedarone
    Target: Cytochrome P450 (CYP450)|sodium channel|adrenergic receptor|potassium channel|calcium channel
    Summary: CYP3A4 and 2D6 inhibitor,moderate
      ≥27.84 mg/mL
  5. YM 511
    B5405 YM 511
    Summary: aromatase (CYP19) inhibitor
      <35.42 mg/mL
  6. 7-Ethoxyresorufin
    B5963 7-Ethoxyresorufin
    Target: Cytochrome P450 (CYP450)
    Summary: Specific subtrate of CYP1A
      Soluble in DMSO
  7. Diosmetin
    B5990 Diosmetin
    Summary: CYP1A1 inhibitor
      insoluble in H2O; ≥13.65 mg/mL
  8. 6,7-dihydroxy Bergamottin
    C4880 6,7-dihydroxy Bergamottin
    Summary: potent inhibitor of CYP3A4
      ≤10 mg/mL
  9. 4-phenyl-1,2,3-Thiadiazole
    C4691 4-phenyl-1,2,3-Thiadiazole
    Summary: selective inhibitor of certain CYP450 enzymes (CYP2B4, CYP2E1)
      ≤10 mg/mL
  10. DDMS
    C5228 DDMS
    Summary: CYP4A2 enzyme inhibitor
      ≤20 mg/mL

Items 1-10 of 17

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