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Signaling Pathways

Items 1-10 of 123

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  1. BMS-345541(free base)
    B4655 BMS-345541(free base)
    Summary: IKK-1/IKK-2 inhibitor,potent and selective
      insoluble in H2O; ≥70 mg/mL
  2. Inauhzin
    B3272 Inauhzin
    Target: Sir2-like Family Deacetylases (Sirtuins)
    Summary: SIRT1 inhibitor
      ≥23.5 mg/mL
  3. Ruxolitinib (INCB018424)
    A3012 Ruxolitinib (INCB018424)
     4 Citation
    Target: JAK
    Summary: JAK inhibitor
      insoluble in H2O; ≥15.32 mg/mL
  4. Rocilinostat (ACY-1215)
    A4083 Rocilinostat (ACY-1215)
     1 Citation
    Target: Histone Deacetylases (HDACs)
    Summary: Selective HDAC6 inhibitor
      ≥21.675 mg/mL
  5. Vorinostat (SAHA, MK0683)
    A4084 Vorinostat (SAHA, MK0683)
     9 Citation
    Target: Histone Deacetylases (HDACs)
    Summary: HDAC inhibitor
      insoluble in EtOH; insoluble in H2O; ≥4.41 mg/mL
  6. Mocetinostat (MGCD0103, MG0103)
    A4089 Mocetinostat (MGCD0103, MG0103)
     2 Citation
    Target: Histone Deacetylases (HDACs)
    Summary: HDAC inhibitor,isotype-selective and potent
      insoluble in EtOH; insoluble in H2O; ≥19.8 mg/mL
  7. JNJ-26481585
    A4090 JNJ-26481585
     3 Citation
    Target: Histone Deacetylases (HDACs)
    Summary: Potent HDAC inhibitor
      insoluble in H2O; insoluble in EtOH; ≥19.2 mg/mL
  8. PCI-34051
    A4091 PCI-34051
     1 Citation
    Target: Histone Deacetylases (HDACs)
    Summary: HDAC8 inhibitor,potent and selective
      insoluble in H2O; insoluble in EtOH; ≥14.8 mg/mL
  9. CUDC-101
    A4092 CUDC-101
     1 Citation
    Target: Histone Deacetylases (HDACs)|EGFR|ErbB
    Summary: Multitargeted HDAC inhibitor
      ≥21.7 mg/mL
  10. ITF2357 (Givinostat)
    A4093 ITF2357 (Givinostat)
     2 Citation
    Target: Histone Deacetylases (HDACs)
    Summary: HDAC inhibitor
      ≥23.8 mg/mL

Items 1-10 of 123

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Category
  1. Bromodomain8item
  2. Aurora Kinase18item
  3. DNA Methyltransferase3item
  4. HDAC34item
  5. Histone Acetyltransferases3item
  6. Histone Demethylases3item
  7. Histone Methyltransferase11item
  8. HIF5item
  9. JAK18item
  10. PARP8item
  11. Pim2item
  12. Protein Ser/Thr Phosphatases3item
  13. Sirtuin7item
  14. Sphingosine Kinase-21 item
Specificity
  1. Selective88item
Reversibility
  1. Reversible6item
  2. Irreversible2item
Target
  1. Cyclin-Dependent Kinases1 item
  2. Histone Deacetylases (HDACs)31item
  3. PI3K1 item
  4. Aurora Kinases18item
  5. MDM21 item
  6. EZH22item
  7. Bromodomains6item
  8. FLT35item
  9. PLK1 item
  10. VEGFR3item
  11. RET1 item
  12. Hydrolase1 item
  13. DOT1L3item
  14. FGFR2item
  15. Nrf21 item
  16. Pim2item
  17. Sir2-like Family Deacetylases (Sirtuins)6item
  18. PP11 item
  19. PP2A1 item
  20. Src4item
  21. Trk Receptors1 item
  22. STAT2item
  23. EGFR2item
  24. Hypoxia Inducible Factors (HIFs)2item
  25. Tankyrases1 item
  26. JAK18item
  27. p3001 item
  28. Syk1 item
  29. EZH11 item
  30. TNKS1 item
  31. Topoisomerases1 item
  32. ErbB1 item
  33. DNA Methyltransferases3item
  34. Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors (HIF-PHIs)1 item
  35. CREBBP1 item
  36. EP3001 item
  37. LRRK21 item
  38. PARP6item
  39. ALK1 item
  40. Bromodomain and Extra-Terminal motif (BET)1 item
  41. phosphatases1 item
  42. COX1 item
  43. G9a1 item
  44. Hck1 item
  45. Histone Demethylases1 item
  46. MNK1 item
  47. AChE1 item
  48. Catechol O-Methyltransferase (COMT)1 item
  49. O6-methylguanine-DNA-methyl-transferase (MGMT)1 item
  50. Protein Arginine Methyltransferases1 item
  51. Cytidine deaminases1 item
  52. PP41 item
  53. c-RET1 item
  54. VEGFR3/FLT41 item
  55. NTRK1/TRKA1 item
  56. CSF-1R/c-Fms1 item
  57. PTP1 item
  58. p532item
  59. HDAC2item
  60. LOX1 item
  61. Adenylyl cyclase1 item
  62. Quinone reductase1 item
  63. Histone Acetyltransferases (HATs)1 item
  64. Trx1 item
  65. HIF-PH1 item
  66. TYK22item
  67. MUSK1 item
  68. MAP3K1 item
  69. p211 item
  70. 5-HT1 item
  71. FGR1 item
  72. YES1 item
  73. Fyn1 item
  74. ARG1 item
  75. LSD1 item
  76. PRMT1 item
  77. GLP1 item
  78. SK1 item
  79. Sirtuin1 item
Related Disease
  1. Acute Myelogenous Leukemia2item
  2. Acute Myeloid Leukemia9item
  3. Bladder Cancer2item
  4. Bladder Carcinoma1 item
  5. Breast Cancer17item
  6. Cancer78item
  7. Castration-resistant Prostate Cancer1 item
  8. Cervical Cancer2item
  9. Chronic Lymphocytic Leukemia1 item
  10. Colon Cancer10item
  11. Colon Carcinoma1 item
  12. Colorectal Cancer4item
  13. Diabetes1 item
  14. Diffuse Large B-cell Lymphoma1 item
  15. Dyskinesia1 item
  16. Epilepsy1 item
  17. Friedreich's Ataxia1 item
  18. Glioblastoma2item
  19. Glioma2item
  20. Hepatic Cancer1 item
  21. Hepatocellular Carcinoma1 item
  22. HIV2item
  23. HIV Infections2item
  24. Immunological Diseases1 item
  25. Inflammatory Bowel Disease1 item
  26. Inflammatory Diseases3item
  27. Leukemia7item
  28. Lung Cancer6item
  29. Lymphoma5item
  30. Melanoma3item
  31. Mixed Lineage Leukemia3item
  32. Multiple Myeloma5item
  33. Myelofibrosis1 item
  34. Myeloma1 item
  35. Neuroblastoma2item
  36. Neuronal Protection1 item
  37. Non-small Cell Lung Cancer5item
  38. Ovarian Cancer4item
  39. Pancreatic Cancer4item
  40. Prostate Cancer11item
  41. Psoriasis1 item
  42. Renal Cancer1 item
  43. Renal Cell Carcinoma2item
  44. Rheumatoid Arthritis3item
  45. Thyroid Cancer1 item
  46. Type 2 Diabetes2item