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Signaling Pathways

Signaling Pathways

B2298 Plinabulin (NPI-2358)

Target: Vascular Disrupting Agents (VDA)

Summary: vascular disrupting agent

Soluble in DMSO
B1115 BAY 87-2243

Target: Hypoxia Inducible Factors (HIFs)

Summary: HIF-1 inhibitor,potent and selective
A4509 PX 12

Target: Trx

Summary: Trx-1 inhibitor

insoluble in H2O; ≥8.75 mg/mL
A8229 ML161

Target: Protease-Activated Receptors

Summary: PAR1 inhibitor

insoluble in H2O; ≥16.4 mg/mL
A8233 DMXAA (Vadimezan)
2 Citation

Target: DT-diaphorases

Summary: Tumnor vascular disrupting agent, apoptosis inducer

insoluble in H2O; insoluble in EtOH; ≥14.1 mg/mL
A8669 AC 55541

Target: PAR

Summary: PAR2 agonist,potent and selective

Soluble in DMSO
A8675 TRAP-6

Target: PAR

Summary: PAR1 agonist

insoluble in EtOH; ≥24.85 mg/mL