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Signaling Pathways

Signaling Pathways

A2024 PD168393

Target: PDGFR|FGFR|EGFR|PKC|insulin

Summary: EGFR inhibitor
A2224 Stattic
5 Citation

Target: STAT

Summary: STAT3 inhibitor,small-molecule and potent

insoluble in H2O; insoluble in EtOH; ≥10.56 mg/mL
A2689 Butein

Target: Src|STAT|EGFR|Angiotensin-Converting Enzymes (ACEs)|5-Lipoxygenases|PTK|enoyl-acyl-carrier protein reductase

Summary: Protein kinase inhibitor

insoluble in H2O; ≥13.6 mg/mL
A8317 Fludarabine Phosphate (Fludara)
2 Citation

Target: STAT

Summary: Inhibits STAT1 activation and DNA synthesis

insoluble in EtOH; ≥17.6 mg/mL
A8319 Dacomitinib (PF299804, PF299)

Target: ErbB

Summary: HER inhibitor

≥23.5 mg/mL
A8322 Neratinib (HKI-272)
1 Citation

Target: EGFR

Summary: HER2/EGFR inhibitor,potent and irreversible

insoluble in H2O; ≥13.93 mg/mL
A8338 NSC 74859
5 Citation

Target: STAT

Summary: Stat3 inhibitor

insoluble in H2O; ≥18.25 mg/mL
A8357 AG-1478

Target: EGFR

Summary: EGFR inhibitor,potent and selective

insoluble in H2O; ≥15.8 mg/mL
A8366 ARRY-380

Target: HER2

Summary: Tyrosine kinase HER2 and p95-HER2 inhibitor

≥28.5 mg/mL
A8375 AZD8931 (Sapitinib)

Target: EGFR|ErbB

Summary: ErbB inhibitor

≥23.7 mg/mL