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Signaling Pathways

Items 1-10 of 71

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  1. SF1670
    B4787 SF1670
    Target: PTEN
    Summary: PTEN inhibitor, potent and specific
      insoluble in EtOH; insoluble in H2O; ≥15.37 mg/mL
  2. THZ2
    A8717 THZ2
     1 Citation
    Target: Cyclin-Dependent Kinases
    Summary: CDK7 inhibitor
      ≥28.3 mg/mL
  3. TAI-1
    B4892 TAI-1
    Target: Hec1
    Summary: Hec1 inhibitor, potent, first-in-class
      ≥43.2 mg/mL
  4. CCG-1423
    B4897 CCG-1423
    Target: Rho
    Summary: RhoA inhibitor
      ≥21 mg/mL
  5. SBE 13 HCl
    B5857 SBE 13 HCl
    Target: PLK
    Summary: Inactive Plk1 inhibitor
      Soluble in DMSO
  6. TAK960
    B5860 TAK960
    Target: PLK
    Summary: Oral and selective PLK1 inhibitor
      ≥28.05 mg/mL
  7. THZ531
    A8736 THZ531
    Target: Cyclin-Dependent Kinases
    Summary: CDK12 and CDK13 covalent inhibitor
      ≥55.8 mg/mL
  8. BML-277
    B1236 BML-277
    Target: Chk
    Summary: Chk2 inhibitor,potent and highly selective
      insoluble in H2O; ≥18.2 mg/mL
  9. Cabazitaxel
    B2157 Cabazitaxel
     3 Citation
    Target: Microtubule/Tubulin
    Summary: Microtubule associated inhibitor
      ≥22.3 mg/mL
  10. KPT-276
    B1463 KPT-276
    Target: nuclear export|CRM1
    Summary: inhibitor of nuclear export (SINE) and CRM1, orally bioavailable
      insoluble in EtOH; insoluble in H2O; ≥19.85 mg/mL

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  1. ATM/ATR4item
  2. Aurora Kinase17item
  3. Cdc421 item
  4. Cdc71 item
  5. Chk4item
  6. CRM11 item
  7. Cyclin-Dependent Kinases18item
  8. E1 enzyme1 item
  9. Ksp1 item
  10. Microtubule/Tubulin5item
  11. RAD511 item
  12. ROCK5item
  13. Rho3item
  14. PERK1 item
  15. PLK8item
  16. PTEN1 item
Specificity
  1. Selective39item
Reversibility
  1. Reversible4item
  2. Irreversible1 item
Target
  1. Cyclin-Dependent Kinases20item
  2. PI3K1 item
  3. Aurora Kinases16item
  4. mTOR1 item
  5. FLT35item
  6. GSK-31 item
  7. PLK9item
  8. Chk4item
  9. VEGFR1 item
  10. PDGFR1 item
  11. RET1 item
  12. Bromodomain-containing proteins(BRDs)1 item
  13. MEK1 item
  14. FGFR1 item
  15. Src3item
  16. Microtubules/Tubulins1 item
  17. ROCK5item
  18. JAK1 item
  19. DNA-PK1 item
  20. Ksp1 item
  21. PKC1 item
  22. RAD511 item
  23. LRRK21 item
  24. PKG1 item
  25. PKA1 item
  26. Myosin light chain kinases (MLCKs)1 item
  27. MK21 item
  28. ATM/ATR4item
  29. Farnesyl Diphosphate Synthases1 item
  30. Cdc421 item
  31. Hck1 item
  32. Cdc71 item
  33. Ubiquitin-activating Enzyme E11 item
  34. Microtubule/Tubulin3item
  35. VEGFR3/FLT41 item
  36. NTRK1/TRKA1 item
  37. CSF-1R/c-Fms1 item
  38. nuclear export1 item
  39. CRM11 item
  40. Hec11 item
  41. Histone Acetyltransferases (HATs)1 item
  42. Rho1 item
  43. Lck1 item
  44. FGR1 item
  45. YES1 item
  46. Fyn1 item
  47. ARG1 item
  48. Rho-kinase1 item
  49. PTEN1 item
Related Disease
  1. Acute Myeloid Leukemia3item
  2. B-lymphoid Malignancies1 item
  3. Breast Cancer4item
  4. Cancer48item
  5. Cervical Cancer1 item
  6. Chronic Lymphocytic Leukemia2item
  7. Colon Cancer3item
  8. Colon Carcinoma1 item
  9. Colorectal Cancer3item
  10. Glioma2item
  11. Leukemia1 item
  12. Lung Cancer2item
  13. Lymphoma2item
  14. Mantle Cell Lymphoma1 item
  15. Melanoma1 item
  16. Multiple Myeloma1 item
  17. Ovarian Cancer3item
  18. Pancreatic Cancer4item
  19. Prostate Cancer2item
  20. Renal Cell Carcinoma1 item
  21. Thyroid Cancer1 item