CCG-1423
Catalog No.
B4897
RhoA inhibitor
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CCG-1423 (CAS: 285986-88-1) is an inhibitor targeting RhoA transcriptional signaling pathways. It disrupts the interaction between myocardin-related transcription factor A (MRTF-A) and importin α/β1, while not affecting the binding of monomeric G-actin to MRTF-A. In cells with Rho overexpression, CCG-1423 exhibits inhibitory effects, leading to inhibition of DNA synthesis, cellular proliferation, and invasion. In highly metastatic melanoma cells with elevated RhoC, it enhances caspase-3 activation, indicating a role in apoptosis modulation. CCG-1423 is utilized in investigating Rho GTPase-mediated processes in cancer and related pathologies.
References:[1]. Minami T, Kuwahara K, Nakagawa Y et al. Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodelling in mice. EMBO J. 2012 Nov 28;31(23):4428-40. doi: 10.1038/emboj.2012.296. Epub 2012 Oct 26.
[2]. Hayashi K, Watanabe B, Nakagawa Y et al. RPEL proteins are the molecular targets for CCG-1423, an inhibitor of Rho signaling. PLoS One. 2014 Feb 18;9(2):e89016. doi: 10.1371/journal.pone.0089016. eCollection 2014.
- 1. Xiang Ren, Zhiping Hei, et al. "The Minute Virus of Canines (MVC) Activates the RhoA/ROCK1/MLC2 Signal Transduction Pathway Resulting in the Dissociation of Tight Junctions and Facilitating Occludin-Mediated Viral Infection." Microorganisms. 2025 Mar 20;13(3):695 PMID: 40142587
- 2. Qiu Zhong, Jiaxin Qi, et al. "In vivo investigation of PEDV transmission via nasal infection: mechanisms of CD4+ T-cell-mediated intestinal infection." Host-Microbial Interactions Research Article 17 March 2025
- 3. Qin Dong, Yuxiao Luo, et al. "RhoA/ROCK1 regulates the mitochondrial dysfunction through Drp1 induced byPorphyromonas gingivalisin endothelial cells." J Cell Mol Med. 2023 Aug;27(15):2123-2135. PMID: 37278388
- 4. Shuo Chen, Fangfang Guo, et al. "Roles of the RhoA-ROCK Signaling Pathway in the Endothelial H2S Production and Vasodilation in Rat Cerebral Arteries." ACS Omega. 2022 May 20;7(22):18498-18508. PMID: 35694456
- 5. Zhao Y, Ge X, et al. "Inhibition of ROCK signaling pathway accelerates enteric neural crest cell-based therapy after transplantation in a rat hypoganglionic model." Neurogastroenterol Motil. 2020;e13895. PMID: 32515097
| Storage | Store at -20°C |
| M.Wt | 454.75 |
| Cas No. | 285986-88-1 |
| Formula | C18H13ClF6N2O3 |
| Solubility | ≥21 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O |
| Chemical Name | N-((1-((4-chlorophenyl)amino)-1-oxopropan-2-yl)oxy)-3,5-bis(trifluoromethyl)benzamide |
| SDF | Download SDF |
| Canonical SMILES | CC(C(Nc(cc1)ccc1Cl)=O)ONC(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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