Azathioprine
Catalog No.
B1892
purine synthesis and GTP-binding protein Rac1 activation inhibitor
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Azathioprine (CAS: 446-86-6) is an immunosuppressive prodrug that is metabolized in vivo to 6-mercaptopurine. It interferes with purine synthesis, leading to the inhibition of DNA, RNA, and protein synthesis, thereby suppressing the proliferation of T and B lymphocytes. Azathioprine is widely utilized in biomedical research to study mechanisms of immune modulation, graft rejection, and the pathophysiology of autoimmune diseases. It is utilized in investigating immunosuppressive protocols and immune homeostasis in transplantation and autoimmune disorder models.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 277.26 |
| Cas No. | 446-86-6 |
| Formula | C9H7N7O2S |
| Solubility | ≥55.56 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O |
| Chemical Name | 6-(3-methyl-5-nitroimidazol-4-yl)sulfanyl-7H-purine |
| SDF | Download SDF |
| Canonical SMILES | C[n](cn1)c(Sc2ncnc3c2[nH]cn3)c1[N+]([O-])=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
