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Calpains

Calpains (calcium-dependent papain-like enzymes) are a family of intracellular enzymes that consist of complex multi-domains and share a calcium-dependent cysteine protease core. With the development of human genome sequencing, a total of fifteen human calpain genes have been identified (CAPN1 to CAPN15). Calpain 1 (μ-calpain) and calpain 2 (m-calpain) are the two most abundant and well studied members of calpain family in mammals, which are heterodimers characterized by consisting of an isoform-specific large subunit (approximately 80 kDa) and a common small subunit (approximately 28 kDa). The large subunit consists of four domains, domain I (function not clear), domain II (cysteine protease domain), domain III (function not clear) and domain IV (Ca2+-binding domain); while the small subunit consists of two domains, domain V (N-terminal glycine-clustering hydrophobic region) and domain VI (C-terminal Ca2+-binding domain).

Compare Products

product-structure
  1. Cat.No. Product Name Information
  2. A4410 Acetyl-Calpastatin (184-210) (human) Calpain I/II inhibitor
  3. A2602 Calpain Inhibitor I, ALLN Calpain I/II/ B/L inhibitor
  4. A2603 Calpain Inhibitor II, ALLM Calpain inhibitor
  5. C5347 Calpain Inhibitor XII reversible and selective inhibitor of calpain I
  6. A4411 Calpeptin Ca2+-dependent protease,calpain inhibitor
  7. A2576 E-64 Cysteine protease inhibitor,irriversible
  8. A4412 MDL 28170 Calpain and cathepsin B inhibitor, selective
  9. A2585 MG-132 Proteasome inhibitor, Cell permeable, reversible
  10. C5830 PD 145305 selective inhibitor of calpains
  11. A4413 PD 150606 Non-peptide calpain inhibitor

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