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Heat shock proteins (HSPs) are a family of highly conserved proteins that are expressed, either constitutively or regulated inductively, in response to a wide range of physiological and environmental insults, such as heat shock. According to molecular weight, mammalian HSPs are classified into four subfamilies, including HSP90 (90 kDa), HSP70 (70 kDa), HSP60 (60 kDa) and small HSPs (15 to 30 kDa), among which HSP90 and HSP70 are two of the most studied stress-inducible HSPs. HSP90 is a highly abundant chaperone protein characterized by containing three relevant domains, including the N-terminal domain, the charged middle linker region and the C-terminal dimerization domain; while HSP70 is an ATP-dependent chaperone protein characterized by containing two distinct functional domains, including a peptide binding domain (PBD) and the amino-terminal ATPase domain (ABD). Collectively HSPs play a fundamental role in maintaining the stability of other cellular proteins.

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  1. Cat.No. Product Name Information
  2. A4056 AT13387 Hsp90 inhibitor
  3. A2213 17-DMAG (Alvespimycin) HCl Hsp90 inhibitor
  4. A3756 Retaspimycin HSP90 inhibitor,antiproliferative and antineoplastic
  5. A3739 PU-H71 Hsp90 inhibitor,potent and selective
  6. A3161 Alvespimycin Hsp90 inhibitor,potent and selective
  7. A4068 SNX-2112 Hsp90 inhibitor,ATP-competitve,potent and selective
  8. A4065 PF-04929113 (SNX-5422) Hsp90 inhibitor,potent and selective
  9. A4064 NVP-BEP800 Oral Hsp90β inhibitor, novel, fully synthetic
  10. A4057 AUY922 (NVP-AUY922) Top Seller Potent Hsp90 inhibitor
  11. A4058 BIIB021 Hsp90 inhibitor,selective and competitive
  12. A4060 Geldanamycin Hsp90 inhibitor,potent and specific
  13. A4061 IPI-504 (Retaspimycin hydrochloride) Hsp90 inhibitor,novel, potent,selective
  14. A4062 KW-2478 Potent Hsp90 inhibitor, novel, non-ansamycin,
  15. C4803 Apoptozole inhibitor of heat shock protein 70 (Hsp70)
  16. C3212 CCT018159 inhibitor of the ATPase activity of Hsp90
  17. B5885 PU-WS13 Grp94-specific Hsp90 inhibitor
  18. A3109 17-AAG Hydrochloride Hsp90 inhibitor,geldanamycin analogue
  19. A4388 XL-888 Hsp90 inhibitor
  20. A4387 VER 155008 HSP 70 inhibitor,adenosine-derived
  21. A4386 Elesclomol (STA-4783) Oxidative stress/apoptosis inducer,potent and novel
  22. A4385 Ganetespib (STA-9090) Top Seller Hsp90 inhibitor,non-geldanamycin
  23. A4054 17-AAG (KOS953) Top Seller Hsp90 inhibitor
  24. B4571 CH5138303 Hsp90 inhibitor, orally available
  25. A4067 Radicicol ATPase/kinase inhibitor
  26. A4063 MPC-3100 Hsp90 inhibitor
  27. B3592 VER-50589 HSP90 inhibitor, potent
  28. B3593 VER-49009 HSP90 inhibitor, potent and selective
  29. B3693 NMS-E973 Hsp90 inhibitor,potent and selective