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p53

The p53 tumor suppressor is a 53 kDa nuclear phosphoprotein of 393 amino acids that is encoded by the TP53 gene (20 kb with 11 exons and 10 introns) and characterized by the presence of several structural and functional domains, including a N-terminus, a central core domain, a C-terminal region, a strongly basic carboxyl-terminal regulatory domain, a nuclear localization signal sequence and three nuclear export signal sequence. The p53 is considered as a major “guardian of genome” for its activities in a wide range of cellular events, including cell-cycle regulation, induction of apoptosis, gene amplification, DNA recombination, chromosomal segregation and cellular senescence.

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  1. Cat.No. Product Name Information
  2. A8804 AMG232 p53-MDM2 inhibitor, novel
  3. C3171 CBL0137 curaxin that activates p53 and inhibits NF-κB
  4. C3192 CBL0137 (hydrochloride) curaxin that activates p53 and inhibits NF-κB
  5. C4483 COTI-2 activates mutant forms of p53
  6. A4476 CP 31398 dihydrochloride p53 stabilizer
  7. A4477 Cyclic Pifithrin-α hydrobromide P53 inhibitor
  8. C4840 GN25 p53-Snail binding Inhibitor
  9. A4478 HLI 373 Hdm2 ubiquitin ligase (E3) inhibitor
  10. A4204 JNJ-26854165 (Serdemetan) P53 activator, blocking Mdm2-p53 interaction
  11. A4479 MIRA-1 Restorer of wild-type p53 conformation/cellular function

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