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The p53 tumor suppressor is a 53 kDa nuclear phosphoprotein of 393 amino acids that is encoded by the TP53 gene (20 kb with 11 exons and 10 introns) and characterized by the presence of several structural and functional domains, including a N-terminus, a central core domain, a C-terminal region, a strongly basic carboxyl-terminal regulatory domain, a nuclear localization signal sequence and three nuclear export signal sequence. The p53 is considered as a major “guardian of genome” for its activities in a wide range of cellular events, including cell-cycle regulation, induction of apoptosis, gene amplification, DNA recombination, chromosomal segregation and cellular senescence.

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  1. Cat.No. Product Name Information
  2. A4206 Pifithrin-α (PFTα) p53 inhibitor
  3. A4228 Nutlin-3 MDM2 antagonist,inhibits MDM2-p53 interaction
  4. C5104 p-nitro-Cyclic Pifithrin-α inactivator of p53
  5. C4840 GN25 p53-Snail binding Inhibitor
  6. C4483 COTI-2 activates mutant forms of p53
  7. C3846 p-nitro-Pifithrin-α inactivator of p53
  8. C3192 CBL0137 (hydrochloride) curaxin that activates p53 and inhibits NF-κB
  9. C3171 CBL0137 curaxin that activates p53 and inhibits NF-κB
  10. B6198 ReACp53 inhibit p53 amyloid formation
  11. B6190 NSC348884 nucleophosmin inhibitor

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