The p53 tumor suppressor is a 53 kDa nuclear phosphoprotein of 393 amino acids that is encoded by the TP53 gene (20 kb with 11 exons and 10 introns) and characterized by the presence of several structural and functional domains, including a N-terminus, a central core domain, a C-terminal region, a strongly basic carboxyl-terminal regulatory domain, a nuclear localization signal sequence and three nuclear export signal sequence. The p53 is considered as a major “guardian of genome” for its activities in a wide range of cellular events, including cell-cycle regulation, induction of apoptosis, gene amplification, DNA recombination, chromosomal segregation and cellular senescence.
- Cat.No. Product Name Information
Pifithrin-α is a synthetic, water-soluble and stable inhibitor of p53 .
- A4228 Nutlin-3 Nutlin-3, a tetra-substituted imidazoline, is a potent and selective small-molecule antagonist of murine double minute 2 (MDM2), which occupies the binding site of p53 in MDM2 and consequently prevent MDM2 binding to p53 leading to the disruption of the autoregulator feedback loop and the fostering of the p53 tumor suppressor network.
- C5104 p-nitro-Cyclic Pifithrin-α
- C4840 GN25
- C4483 COTI-2
- C3846 p-nitro-Pifithrin-α
- C3192 CBL0137 (hydrochloride)
- C3171 CBL0137
- B6198 ReACp53
- B6190 NSC348884