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Bax

BAX (the BCL-2-associated X protein), a cardinal pro-apoptotic member of the BCL-2 family, is a latent, cytosolic and monomeric protein that plays an important role in the mitochondria-dependent apoptotic pathway. The nuclear magnetic resonance (NMR) spectroscopic analysis suggests that the structure of Bax consists of nine α-helices (α1 to α9) connected by short loops, in which α5, α6 and α9 are involved in the interaction of Bax with outer mitochondrial membrane (OMM). Bax remains inactive in cytosol and goes through conformational changes triggered by a cell death signal to insert, oligomerize and form large pores through the OMM with the releasing of different apoptogenic factors.

product-structure
  1. Cat.No. Product Name Information
  2. A3218 BAM7 BAX activator,direct and selective
  3. A4459 Bax channel blocker Inhibitor of Bax-mediated mitochondrial cytochrome c release
  4. A4460 Bax inhibitor peptide P5 Bax inhibitor
  5. A4461 Bax inhibitor peptide V5 Bax inhibitor
  6. A4462 Bax inhibitor peptide, negative control Peptide inhibit Bax translocation to mitochondria
  7. A4483 PRIMA-1 BAX inhibitor
  8. A4484 PRIMA-1MET Restore mutant p53 activity, induce BAX and PUMA

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