BAX (the BCL-2-associated X protein), a cardinal pro-apoptotic member of the BCL-2 family, is a latent, cytosolic and monomeric protein that plays an important role in the mitochondria-dependent apoptotic pathway. The nuclear magnetic resonance (NMR) spectroscopic analysis suggests that the structure of Bax consists of nine α-helices (α1 to α9) connected by short loops, in which α5, α6 and α9 are involved in the interaction of Bax with outer mitochondrial membrane (OMM). Bax remains inactive in cytosol and goes through conformational changes triggered by a cell death signal to insert, oligomerize and form large pores through the OMM with the releasing of different apoptogenic factors.
- Cat.No. Product Name Information
- A4484 PRIMA-1MET PRIMA-1MET selectively restores the activity of mutant p53 in tumor cells.
- A4483 PRIMA-1 Selectively restores mutant p53 activity in tumor cells via activation of Bax and PUMA. Induces apoptosis and inhibits growth of human tumors with mutant p53.
- A4459 Bax channel blocker Potent inhibitor of Bax-mediated mitochondrial cytochrome c release (IC50 = 0.52 μM). Suggested to inhibit Bax channel formation/activity.
- A4460 Bax inhibitor peptide P5 Cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria; designed from Ku70, a protein that is suggested to suppress the mitochondrial translocation of Bax. Inhibits Bax-mediated apoptosis in vitro.
- A3218 BAM7 BAM7 is a direct and selective activator of BAX with IC50 value of 3.3uM .
- A4461 Bax inhibitor peptide V5 Cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria; designed from Ku70, a protein that is suggested to suppress the mitochondrial translocation of Bax. Inhibits Bax-mediated apoptosis in vitro.
- A4462 Bax inhibitor peptide, negative control Negative control peptide for the Bax inhibitor peptides V5 and P5 , which inhibit Bax translocation to mitochondria and Bax-mediated apoptosis in vitro.