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Home >> Signaling Pathways >> Apoptosis >> Caspase

Caspase

Caspases (cysteine-dependent aspartate specific ptotease) are a family of cysteine proteases that play an essential role in cell apoptosis. Caspases contain a conserved QACXG pentapeptide active site motif and are characterized by specificity for aspartic acid in the P1 position. The synthesis of caspases involves the activation of inactive proenzymes, which contain an N-terminal peptide (prodomain) together with two subunits (one small and one large), following cleavage at specific aspartate cleavage sites. Caspases can be classified into three subfamilies, due to phylogenetic analysis, including an ICE subfamily (caspases-1, -4 and -5), a CED-3/CPP32 subfamily (caspases-3, -6, -7, -8, -9 and -10) and an ICH-1/Nedd2 subfamily (caspase-2).

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Biochemicals

  1. Cat.No. Product Name Information
  2. A1902 Z-VAD-FMK Cell-permeable, irreversible pan-caspase inhibitor
  3. C5667 Se-Aspirin nonsteroidal anti-inflammatory drug
  4. C4981 Z-Asp-CH2-DCB caspase inhibitor
  5. C5528 Ac-DEVD-CMK cell-permeable, and irreversible inhibitor of caspase
  6. C5524 Ac-DEVD-AFC fluorogenic substrate for activated caspase-3
  7. C4468 NS3694 inhibits apoptosome formation and caspase activation
  8. A8955 Z-YVAD-FMK Caspase-1 inhibitor
  9. A9901 Caspase Inhibitor Set I Caspase Inhibitors
  10. A1925 Caspase-3/7 Inhibitor I Top Seller Caspase-3/7 inhibitor
  11. A1901 Q-VD-OPh hydrate Top Seller Cell-permeable, irreversible pan-caspase inhibitor
  12. A8238 VX-765 Caspase-1 inhibitor,potent and selective
  13. A1923 Z-VEID-FMK Top Seller Caspase-6 inhibitor
  14. A1922 Z-VDVAD-FMK Top Seller Caspase-2 inhibitor
  15. A1921 Z-DQMD-FMK Top Seller Caspase-3 inhibitor,cell-permeable
  16. A1920 Z-DEVD-FMK Top Seller Caspase-3 inhibitor
  17. A8165 Q-VD(OMe)-OPh Top Seller Pan-caspase inhibitor
  18. A8177 PAC-1 Top Seller Procaspase-3 activator
  19. A1930 Apoptosis Inhibitor Top Seller Associate with caspase-3 inhibition
  20. B3232 Z-IETD-FMK Caspase-8 inhibitor
  21. B3233 Z-LEHD-FMK Irreversible Caspase-9 inhibitor.
  22. A1924 Z-WEHD-FMK Caspase 5 inhibitor,potent,cell-permeable and irreversible
  23. A1904 Boc-D-FMK Pan-caspase inhibitor
  24. A8321 Cisplatin Top Seller Inhibits DNA synthesis,chemotherapy drug
  25. A4418 Ac-IEPD-AFC Recognition motif for serine protease granzyme B
  26. A4419 Ac-LEHD-AFC Fluorogenic caspase substrate
  27. A3424 Gambogic Acid Caspase activator and apoptosis inducer
  28. A4016 Apoptosis Activator 2 Indoledione caspase activator, cell-permeable
  29. A8170 Z-FA-FMK Top Seller Cysteine proteases inhibitor
  30. A4416 AZ 10417808 Caspase-3 inhibitor,selective non-peptide
  31. A4417 Ivachtin Caspase-3 inhibitor
  32. A4420 PETCM Caspase-3 activator
  33. B4618 Emricasan potent irreversible pan-caspase inhibitor