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Proteasome

The proteasome is a large multisubunit complex of approximately 2.5 MDa that mediates a wide range of physiological and pathological cellular processes by selectively degrading unnecessary proteins in eukaryotes. The structure of a proteasome is comprised of the catalytic core particle (CP) and two terminal regulatory particles (RPs). The CP (also known as the 20S proteasome) is a barrel shaped multisubunit complex (approximately 750 kDa) consisting of four axially stacked heptameric rings (two outer α-rings and two inner β-rings) with 7 subunits in each ring, where three β subunits (β1, β2 and β5) contain catalytically active threonine residues and are associated with caspase-like, trypsin-like and chymotrypsin-like activities respectively.

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product-structure
  1. Cat.No. Product Name Information
  2. A2601 Aclacinomycin A Topoisomerase I and II inhibitor
  3. A8163 AM 114 20S proteasome inhibitor
  4. A4014 Artemether (SM-224) Semi-synthetic derivative of artemisinin
  5. A2614 Bortezomib (PS-341) Proteasome Inhibitor
  6. A1933 Carfilzomib (PR-171) Proteasome inhibitor,epoxomicin analog
  7. A2604 Celastrol Antioxidant, anti-inflammatory and immunosuppressive agent
  8. A4009 CEP-18770 Proteasome inhibitor
  9. A2578 Clasto-Lactacystin β-lactone Proteasome inhibitor
  10. A8172 Dihydroeponemycin Proteasome inhibitor,antitumor reagent,eponemycin ddrivative
  11. A2606 Epoxomicin Proteasome inhibitor

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