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NAE (NEDD8-activating enzyme) catalyzes the initial step of the neddylation signaling that regulates CRLs (cullin-ring ubiquitin ligases) activities. Its downstream effect is linked to cancer cell growth and survival.

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  2. B1036 MLN4924 NAE inhibitor
  3. A3629 MLN4924 HCl salt NAE inhibitor

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