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Cytochrome P450 are a family of heme-containing monoxygenases catalyzing the metabolism of xenobiotics in the body where P450 enzymes use O2 and two electrons provided by NAD(P)H with the help of redox partner flavoproteins and iron-sulfur proteins to catalyze the monooxygenation of a variety of substrates. Based on how electrons from NAD(P)H are delivered to the catalytic site, P450 enzymes are divided into four classes, including Class I requiring both an FAD-containing reductase and an iron sulfur redoxin, Class II requiring only an FAD/FMN-containg P450 reductase, Class III requiring no electron donor and Class IV requiring electrons directly from NAD(P)H.

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  1. Cat.No. Product Name Information
  2. B1240 (+)-Ketoconazole Potent inhibitor of cytochrome P450c17
  3. C3414 (S)-Mephenytoin substrate of the cytochrome P450 (CYP) isoform CYP2C19
  4. C4562 2,3-dihydrothieno-Thiadiazole Carboxylate CYP450 enzymes (CYP2E1 and CYP2B4) inhibitor
  5. C5047 2-Phenyl-2-(1-piperidinyl)propane mechanism-based inactivator of human cytochrome P450 (CYP) 2B6
  6. C4429 4-phenyl-5-methyl-1,2,3-Thiadiazole CYP2B4 and CYP2E1 inhibitor
  7. A4240 Abiraterone Potent CYP17 inhibitor
  8. A8202 Abiraterone acetate Cytochrome p450 17a1 inhibitor
  9. A4308 Alizarin Chelator for calcium,used to stain calcium deposites,Alizarin complexone is used for bone staining to study bone remodeling
  10. A4318 Avasimibe ACAT inhibitor,orally bioavailable
  11. C5344 HET0016 inhibitor of 20-HETE formation

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