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FAAH

Fatty acid amide hydrolase (FAAH), belonging to an amidase-signature (AS) protein family, is a membrane-bound protein predominantly in microsomal and mitochondrial fractions that catalyzes the hydrolysis of several bioactive lipids, including anandamide, 2-arachidonoylglycerol (2-AG) and oleamide. The mammalian FAAHs are 63 kDa (579 amino acids in length) proteins characterized by containing several domains defined by homology and function, including, a highly conserved seine-and-glycine-rich AS domain, a predicted transmembrane domain and a proline rich domain. Results of mutation studies suggest, unlike other members of AS protein family, the catalytic activity of FAAH is not associated with the Ser-His-Asp triad but possibly with Ser217 and Lys142.

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  1. Cat.No. Product Name Information
  2. C4279 4-(n-nonyl) Benzeneboronic Acid FAAH and MAGL inhibitor
  3. A4361 JNJ-1661010 FAAH inhibitor,potent and selective
  4. C4122 JNJ-42165279 FAAH inhibitor
  5. C4983 JP83 irreversible fatty acyl amide hydrolase (FAAH) inhibitor
  6. B7701 JZL 195 Dual inhibitor of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL)
  7. A3571 LY2183240 Blocker of anandamide uptake,highly potent
  8. C5178 Methyl α-Linolenyl Fluorophosphonate inhibitor of phospholipases, FAAH
  9. C5452 Monoacylglycerol Lipase Inhibitor 21 inhibitor of monoacylglycerol lipase (MAGL) and FAAH
  10. C5619 N-Benzylpalmitamide inhibitor of fatty acid amide hydrolase (FAAH)
  11. C4251 Oleoyl Ethyl Amide FAAH inhibitor with potential analgesic and anxiolytic activity

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