Dihydrofolate reductase (DHFR) is an enzyme that catalyzes the reduction of dihydrofolate (H2F) to tetrahydrofolate (H4F) utilizing nicotinamide adenine dinucleotide phosphate (NADPH) as the hydride (H-) donor, in which the pro-R hydrogen of NADPH is transferred to C6 of the pteridine ring with concomitant protonation at the N5 position. The functional DHFR gene (approximately 30 kb with six exons and five introns) has been identified to encode DHFR enzyme. Human DHFR enzyme is a monomeric protein of 186 amino acids, which is characterized by containing a highly conserved dinucleotide-binding domain consisting of seven parallel and one antiparallel β-strands intercalated by α-helices.
- Cat.No. Product Name Information
- C5763 Cycloguanil (hydrochloride) inhibitor of dihydrofolate reductase (DHFR)
- A4347 Methotrexate Folate antagonist,inhibits DFHR
- A4390 Pemetrexed TS, DHFR,GARFT and AICARFT inhibitor
- A3707 Pemetrexed disodium hemipenta hydrate Antifolate and antimetabolite agent
- A4350 Pralatrexate Antifolate,a folate analog
- A4353 Pyrimethamine DHFR inhibitor