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JAK

Janus kinases (JAKs), belonging to a distinct family of tyrosine kinases, are non-receptor tyrosine kinases that transduce signals of cytokine receptors via diverse signal transduction pathways. Mammalian JAK family consists of four structurally similar members, JAK1, JAK2, JAK3 and Tyrosine kinase 2 (TYK2), which are characterized by containing seven JAK homology (JH) domains. The presence of JH1 and JH2 domains is the most intriguing feature of JAK proteins. JH1 domain is the main catalytic domain; while JH2 is usually considered as a catalytically inactive pseudokinase domain. However, results of recent studies have shown that JH2 acts as a dual-specificity protein kinase to phosphorylate two regulatory sites (Ser523 and Tyr570) in JAK2.

Research Area

  1. Cat.No. Product Name Information
  2. B1259 (3R,4S)-Tofacitinib Novel inhibitor of JAK3
  3. B1031 (3S,4S)-Tofacitinib Inhibitor of JAK3
  4. B1258 (3S,4R)-Tofacitinib Novel inhibitor of JAK3
  5. B1130 GLPG0634 JAK1 inhibitor
  6. A4517 ZM 449829 JAK3 inhibitor
  7. A4513 Lestaurtinib JAK2/FLT3/TrkA inhibitor
  8. A4152 BMS-911543 JAK2 inhibitor,selective small molecule
  9. A4151 ZM 39923 HCl JAK3 inhibitor,potent and selective
  10. A4150 WHI-P154 JAK3 inhibitor
  11. A4148 NVP-BSK805 2HCl JAK2 inhibitor

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