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Aurora Kinase

Aurora kinases are a family of serine-threonine kinases of three highly homologous members, including aurora A kinase, aurora B kinase and aurora C kinase, which are responsible for chromosome assembly and segregation during mitosis. Aurora kinases are characterized by two domains: a regulatory domain in the NH2 terminus and a catalytic domain in the COOH terminus, in which an A-Box and a D-Box found correspondingly in each domain are responsible for protein degradation. Aurora A kinase plays an important role in centrosome function and duplication, mitotic entry and bipolar spindle assembly; while Aurora B kinase is the catalytic component of the chromosomal passenger complex regulating the accurate segregation of the chromatids at mitosis, histone modification and cytokinesis. Aurora C kinase is less studied and expressed restrictedly in the testes.

Research Area

  1. Cat.No. Product Name Information
  2. A4119 AMG-900 Aurora kinase inhibitor
  3. A4488 Anacardic acid HAT inhibitor
  4. A4117 AT9283 Aurora kinase/JAK inhibitor
  5. A4126 Aurora A Inhibitor I Aurora A inhibitor
  6. A3214 AZD1152 Aurora B kinase inhibitor,highly potent and selective
  7. A4112 Barasertib (AZD1152-HQPA) Aurora Kinase B inhibitor, Potent and selective
  8. B6014 BI-847325 dual inhibitor of MEK and Aurora kinases
  9. A4131 CCT129202 Aurora kinase inhibitor,ATP-competitive and potent
  10. A4132 CCT137690 Aurora A/B/C inhibitor
  11. A4125 CYC116 Potent Aurora A/B inhibitor

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