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Aurora Kinase

Aurora kinases are a family of serine-threonine kinases of three highly homologous members, including aurora A kinase, aurora B kinase and aurora C kinase, which are responsible for chromosome assembly and segregation during mitosis. Aurora kinases are characterized by two domains: a regulatory domain in the NH2 terminus and a catalytic domain in the COOH terminus, in which an A-Box and a D-Box found correspondingly in each domain are responsible for protein degradation. Aurora A kinase plays an important role in centrosome function and duplication, mitotic entry and bipolar spindle assembly; while Aurora B kinase is the catalytic component of the chromosomal passenger complex regulating the accurate segregation of the chromatids at mitosis, histone modification and cytokinesis. Aurora C kinase is less studied and expressed restrictedly in the testes.

Research Area

  1. Cat.No. Product Name Information
  2. A8807 MK-8745 Aurora A inhibitor,potent and selective
  3. A3760 Reversine A3 adenosine receptor antagonist,ARK-1/-2/-3 inhibitor
  4. A3214 AZD1152 Aurora B kinase inhibitor,highly potent and selective
  5. A4113 ZM 447439 Aurora Kinase inhibitor,potent and selective
  6. A4112 Barasertib (AZD1152-HQPA) Aurora Kinase B inhibitor, Potent and selective
  7. A4111 VX-680 (MK-0457,Tozasertib) Aurora kinase inhibitor
  8. A4110 MLN8237 (Alisertib) Aurora A Kinase inhibitor, Potent and selective
  9. C3823 Phthalazinone pyrazole Aurora A kinase inhibitor
  10. B6014 BI-847325 dual inhibitor of MEK and Aurora kinases
  11. A4489 TC-A 2317 hydrochloride Aurora kinase A inhibitor,potent and selective

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