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Chromatin/Epigenetics

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Products for  Chromatin/Epigenetics

  1. Cat.No. Product Name Information
  2. B1031 (3S,4S)-Tofacitinib Inhibitor of JAK3
  3. B1258 (3S,4R)-Tofacitinib Novel inhibitor of JAK3
  4. B1130 GLPG0634 JAK1 inhibitor
  5. B1182 ABC294640 Sphingosine kinase 2 inhibitor,selective and competitive
  6. B1115 BAY 87-2243 HIF-1 inhibitor,potent and selective
  7. B1141 Varenicline Hydrochloride α4β2 nicotinic receptor agonist
  8. A8807 MK-8745 Aurora A inhibitor,potent and selective
  9. A8547 Tubastatin A HCl HDAC6 inhibitor,potent and selective
  10. A1877 XAV-939 Tankyrase 1/2 inhibitor
  11. A8223 CID 2011756 PKD inhibitor

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