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Chromatin/Epigenetics

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Products for  Chromatin/Epigenetics

  1. Cat.No. Product Name Information
  2. B3274 CCT007093 PPM1D inhibitor
  3. B3272 Inauhzin SIRT1 inhibitor
  4. B3276 MG 149 HAT inhibitor
  5. A1910 Bromodomain Inhibitor, (+)-JQ1 Top Seller BET bromodomain inhibitor
  6. B4917 Ischemin sodium salt
  7. B4918 OXF BD 02
  8. B5887 BET bromodomain inhibitor Potent and selective inhibitor for BRD4
  9. B5973 PFI 4 Potent and selective BRPF1 Bromodomain inhibitor
  10. B5998 GSK2801 inhibitor of BAZ2A and BAZ2B bromodomains
  11. B4916 GSK 5959
  12. B4915 BAZ2-ICR
  13. A8181 (-)-JQ1 Top Seller BET bromodomain inhibitor
  14. A4490 I-CBP 112 CBP/EP300 bromodomain inhibitor
  15. A4491 SGC-CBP30 Inhibitor of CREBBP/EP300 bromodomain,potent
  16. B7744 PFI 3 inhibitor of polybromo 1 and SMARCA4
  17. B5670 I-BET 151 hydrochloride New Product
  18. A9500 GW841819X BET bromodomain inhibitor
  19. B4821 BET-BAY 002 BET inhibitor, potent
  20. B4895 OF-1 BRPF1B and BRPF2 bromodomain inhibitor
  21. B1500 I-BET151 (GSK1210151A) Selective BET inhibitor
  22. B1498 I-BET-762 BET inhibitor,highly potent
  23. B1499 RVX-208 Potent BET bromodomain inhibitor
  24. A8810 UNC669 L3MBTL antagonist,potent and selective
  25. A3901 UNC1215 Chemical probe for the methyllysine (Kme)
  26. A3692 OTX-015 BRD inhibitor
  27. A3445 GSK 525768A inactive stereoisomer of I-BET-762
  28. A4186 Bromosporine Bromodomain inhibitor,non-selective
  29. A4184 PFI-1 (PF-6405761) BET inhibitor
  30. B1081 CPI-203 BET bromodomain inhibitor
  31. B1013 GSK1324726A BET proteins inhibitor
  32. B1012 MS436 BRD4 inhibitor
  33. A8807 MK-8745 Aurora A inhibitor,potent and selective
  34. A3760 Reversine A3 adenosine receptor antagonist,ARK-1/-2/-3 inhibitor
  35. A3214 AZD1152 Aurora B kinase inhibitor,highly potent and selective
  36. A4113 ZM 447439 Aurora Kinase inhibitor,potent and selective
  37. A4112 Barasertib (AZD1152-HQPA) Top Seller Aurora Kinase B inhibitor, Potent and selective
  38. A4111 VX-680 (MK-0457,Tozasertib) Top Seller Aurora kinase inhibitor
  39. A4110 MLN8237 (Alisertib) Top Seller Aurora A Kinase inhibitor, Potent and selective
  40. A4128 PF-03814735 Aurora A/B inhibitor
  41. A3804 SCH-1473759 Aurora A/B inhibitor
  42. A3939 XL228 IGF1R/AURORA /FGFR1-3/ABL/SRC family kinases inhibitor
  43. A4489 TC-A 2317 hydrochloride Aurora kinase A inhibitor,potent and selective
  44. B6014 BI-847325 dual inhibitor of MEK and Aurora kinases
  45. A4127 GSK1070916 Aurora B/C inhibitor
  46. A4126 Aurora A Inhibitor I Aurora A inhibitor
  47. A4130 ENMD-2076 Selective Aurora A/Flt3 inhibitor
  48. A4129 ENMD-2076 L-(+)-Tartaric acid Aurora kinases inhibitor
  49. A4132 CCT137690 Aurora A/B/C inhibitor
  50. A4118 Hesperadin Top Seller Aurora B kinase inhibitor
  51. A4119 AMG-900 Aurora kinase inhibitor
  52. A4121 SNS-314 Mesylate Aurora A/B/C kinases inhibitor, potent and selective
  53. A4124 TAK-901 Novel Aurora A/B inhibitor
  54. A4125 CYC116 Potent Aurora A/B inhibitor
  55. A4131 CCT129202 Aurora kinase inhibitor,ATP-competitive and potent
  56. A4114 MLN8054 Aurora A inhibitor
  57. A4115 JNJ-7706621 Potent CDK/Aurora kinase inhibitor
  58. A4116 Danusertib (PHA-739358) Top Seller Pan-aurora kinase inhibitor
  59. A4117 AT9283 Aurora kinase/JAK inhibitor
  60. A4120 MK-5108 (VX-689) Aurora-A kinase inhibitor,highly selective
  61. A4122 PHA-680632 Aurora kinase inhibitor,novel and potent
  62. A4488 Anacardic acid HAT inhibitor
  63. A8191 Nanaomycin A Top Seller DNMT3B inhibitor
  64. A4176 Thioguanine Purine antimetabolite
  65. A1915 Zebularine DNA methylation inhibitor
  66. A1906 Decitabine (NSC127716, 5AZA-CdR) Deoxycytidine analog and cellular diifferentiation inducer
  67. A1907 5-Azacytidine DNA methyltransferase inhibitor.
  68. A1912 Lomeguatrib Top Seller MGMT inhibitor
  69. A1913 RG 108 DNA methyltransferase inhibitor
  70. A8901 Nanaomycin C Nanaomycin C
  71. A4178 SGI-110 DNA methyltransferases inhibitor,potent
  72. A4103 LAQ824 (NVP-LAQ824,Dacinostat) HDAC inhibitor,potent and novel
  73. A4105 M344 Top Seller HDAC inhibitor,potent and cell-permeable
  74. A4501 Tubacin HDAC6 inhibitor,potent,selective,reversible,cell-permeable
  75. A8547 Tubastatin A HCl Top Seller HDAC6 inhibitor,potent and selective
  76. B1141 Varenicline Hydrochloride α4β2 nicotinic receptor agonist
  77. B4890 HPOB HDAC6 inhibitor, potent and selective
  78. A4099 Valproic acid sodium salt (Sodium valproate) HDAC inhibitor
  79. A4098 PCI-24781 (CRA-024781) Pan-HDAC inhibitor
  80. A4096 Belinostat (PXD101) Hydroxamate-type HDAC inhibitor
  81. A8171 Entinostat (MS-275,SNDX-275) Top Seller HDAC1 and HDAC3 inhibitor
  82. A8178 Panobinostat (LBH589) Top Seller HDAC inhibitor
  83. A8183 Trichostatin A (TSA) Top Seller HDAC inhibitor
  84. A8176 Apicidin Potent HDAC inhibitor
  85. A4084 Vorinostat (SAHA, MK0683) Top Seller HDAC inhibitor
  86. A4089 Mocetinostat (MGCD0103, MG0103) Top Seller HDAC inhibitor,isotype-selective and potent
  87. A4090 JNJ-26481585 Top Seller Potent HDAC inhibitor
  88. A4108 Resminostat (RAS2410) Potent HDAC inhibitor
  89. A4095 Pracinostat (SB939) Top Seller Pan-HDAC inhibitor
  90. B5936 ACY-241 Selective and orally active HDAC6 inhibitor
  91. B5949 BG45 Novel HDAC3-selective inhibitor
  92. B5967 UF 010 Novel and selective class I HDAC inhibitor
  93. B5968 BML-210(CAY10433) Novel HDAC inhibitor
  94. B5969 2-hexyl-4-Pentynoic Acid Potent and robust HDACs inhibitor
  95. B5976 Suberohydroxamic Acid HDAC inhibitor
  96. B5916 Chidamide Novel HDAC inhibitor
  97. A8806 TMP269 HDAC 4/5/7/9 inhibitor
  98. A4097 CUDC-907 Potent PI3K/HDAC inhibitor
  99. A4083 Rocilinostat (ACY-1215) Top Seller Selective HDAC6 inhibitor
  100. N1315 Parthenolide Parthenolide is a sesquiterpene lactone and active principle of feverfew (Chrysanthemum parthenium)
  101. A4100 Droxinostat Selective HDAC inhibitor
  102. A4101 Tubastatin A HDAC6 inhibitor,potent and selective
  103. A3761 RG2833 Brain-penetrant HDAC inhibitor
  104. A8803 RGFP966 Specific HDAC3 inhibitor
  105. A9906 HDAC Set I
  106. A4493 KD 5170 HDAC inhibitor
  107. A3755 Resminostat hydrochloride HDAC inhibitor
  108. A3860 Tasquinimod Antiangiogenic and antineoplastic agent
  109. A3348 Daminozide KDM2A inhibitor
  110. A8173 Romidepsin (FK228, depsipeptide) Top Seller HDAC1/HDAC2 inhibitor,potent and selective
  111. A3305 CHAPS Zwitterionic detergent for membrane proteins,nondenaturing
  112. A4102 CI994 (Tacedinaline) Top Seller HDAC inhibitor
  113. A4498 SBHA HDAC1/HDAC3 inhibitor,cell-permeable
  114. A4500 TCS HDAC6 20b Selective HDAC6 inhibitor
  115. A4494 LMK 235 HDAC4/HDAC5 inhibitor
  116. A4091 PCI-34051 HDAC8 inhibitor,potent and selective
  117. A4092 CUDC-101 Multitargeted HDAC inhibitor
  118. A4093 ITF2357 (Givinostat) Top Seller HDAC inhibitor
  119. A4106 Scriptaid Top Seller HDAC inhibitor,novel and cell-permeable
  120. A4107 Sodium Phenylbutyrate Histone deacetylase inhibitor
  121. A4094 MC1568 Top Seller Class II HDAC inhibitor,potent and
  122. A4104 AR-42 (OSU-HDAC42) Top Seller HDAC inhibitor,novel and potent
  123. A4495 NCH 51 Histone deacetylase (HDAC) inhibitor
  124. A4496 NSC 3852 HDAC inhibitor
  125. A4497 Pyroxamide HDAC1 inhibitor
  126. A4499 TC-H 106 HDAC inhibitor
  127. B4655 BMS-345541(free base) IKK-1/IKK-2 inhibitor,potent and selective
  128. B4106 4SC-202 Class I HDAC inhibitor
  129. B3704 Nexturastat A HDAC6 inhibitor,highly potent and selective
  130. B1251 Valproic acid HDAC1 inhibitor
  131. B1577 C646 HAT p300-CBP inhibitor,cell-permeable
  132. A8712 MCB-613 stimulator of steroid receptor coactivator (SRC)
  133. B4946 Garcinol
  134. B4945 IWP 12
  135. B4887 Remodelin NAT10 inhibitor
  136. B7739 L002 New Product
  137. B7241 VULM 1457 New Product
  138. A4492 NU 9056 KAT5 (Tip60) HAT inhibitor
  139. B6987 CI 976 New Product
  140. B7679 (R)-(+)-Etomoxir sodium salt New Product
  141. B7250 YM 750 New Product
  142. B1602 Donepezil HCl AChE inhibitor
  143. A4190 GSK J4 HCl Inhibitor of H3K27 demethylase JMJD3,potent and cell-permeable
  144. B6084 AS8351 histone demethylase inhibitor
  145. B5972 2,4-Pyridinedicarboxylic Acid Histone LSD inhibitor
  146. B5879 GSK2879552 Novel and irreversible LSD1 inhibitor
  147. B5959 GSK J4 free base GSK J4 free base
  148. B4983 GSK-LSD1 2HCl
  149. B4930 TC-E 5002
  150. B4894 SP2509 Demethylase 1 (LSD1) antagonist, novel Lysine-specific
  151. B4835 CBB1003
  152. B5784 RN 1 dihydrochloride LSD1 inhibitor, potent and selective
  153. B5686 GSK J5 New Product
  154. B5685 GSK J2 New Product
  155. B5607 IOX 1 histone demethylase JMJD inhibitor
  156. B7514 Tranylcypromine hydrochloride New Product
  157. B4891 ML324 JMJD2 demethylase inhibitor, potent and cell-permeable
  158. B1578 Tranylcypromine (2-PCPA) HCl Monoamine oxidase inhibitor
  159. B1580 OG-L002 LSD1 inhibitor,potent and specific
  160. B1263 CBB1007 LSD1 inhibitor,potent and selective
  161. A4191 GSK J1 H3K27 demethylase JMJD3 inhibitor
  162. A1146 Histone-H2A-(107-122)-Ac-OH Histone-H2A peptide
  163. A4171 EPZ005687 Top Seller EZH2 inhibitor,potent and selective
  164. A4168 Entacapone COMT inhibitor
  165. A4166 EPZ5676 DOT1L inhibitor,potent and SAM competitive
  166. A1905 3-Deazaneplanocin,DZNep Top Seller Cell-permeable histone methyltransferase inhibitor
  167. B4989 EPZ015666 PRMT5 inhibitor
  168. B5913 C7280948 Novel PRMT1 inhibitor
  169. B6048 SGC707 PRMT3 inhibitor
  170. B6081 BAY-598 SMYD2 inhibitor
  171. B6082 EPZ031686 SMYD3 inhibitor
  172. B6085 AMI5 protein methyltransferase inhibitor
  173. B6088 EPZ020411 PRMT6 inhibitor
  174. B4949 WDR5 0103 WD repeat-containing protein 5 (WDR5) antagonist
  175. B4948 UNC 2400 negative control of UNC1999
  176. A4503 UNC 0224 G9a histone methyltransferase inhibitor
  177. A1909 BIX 01294 G9a and GLP inhibitor
  178. A1908 AMI-1 PRMT1 inhibitor
  179. A8221 EPZ-6438 EZH2 inhibitor,potent and selective
  180. B7718 (R)-PFI 2 hydrochloride SETD7 histone lysine methyltransferase inhibitor
  181. B7750 TC-E 5003 PRMT1 inhibitor, potent
  182. B7756 C 21 Protein arginine methyltransferase 1 (PRMT1) inhibitor
  183. B7757 UNC 0642 G9a and GLP histone lysine methyltransferase inhibitor
  184. B4947 A 366 G9a/GLP histone lysine methyltransferase inhibitor
  185. B4875 PFI-2 SETD7 methyltransferase inhibitor
  186. A1914 UNC0638 G9a/GLP HMTase inhibitor, potent and selective
  187. A8182 3-Deazaneplanocin A (DZNep) hydrochloride SAHH and ENZ2 inhibitor
  188. A4502 Chaetocin SUV39H1 Inhibitor
  189. B1256 AZ505 ditrifluoroacetate SMYD2 inhibitor
  190. B1255 AZ505 SMYD2 inhibitor,potent and selective
  191. B1127 UNC 0631 G9a inhibitor
  192. B1126 UNC0321 G9a inhibitor
  193. B1622 SGI-1027 DNMT inhibitor
  194. A4504 UNC 0646 G9a and GLP inhibitor
  195. A4167 SGC 0946 DOT1L inhibitor,highly potent and selective
  196. A4170 EPZ004777 DOT1L inhibitor
  197. B1581 EPZ004777 HCl DOT1L inhibitor,potent and selective
  198. B1583 UNC1999 EZH2 inhibitor
  199. B1582 MM-102 MLL1 inhibitor,high-affinity peptidomimetic
  200. A4187 FG-4592 (ASP1517) Top Seller HIF prolyl-hydroxylase inhibitor
  201. B1115 BAY 87-2243 HIF-1 inhibitor,potent and selective

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