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Alzheimer

Alzheimer

Alzheimer’s disease (AD), a neurodegenerative disorder, is the most common cause of progressive dementia. Two microscopic characteristics of AD are extracellular amyloid plaques and intracellular neurofibrillary tangles. Amyloid β peptide (Aβ), derived from amyloid precursor protein (APP) by sequential protein cleavage, and other metabolites deposit around neurons and form amyloid plaques, which contribute to the disease’s pathogenesis. The neurofibrillary tangles are formed by the aggregation of phosphorylated tau proteins. Under pathogenic conditions, tau accumulates in dendritic spines and interferes with neurotransmission. The Aβoligomer promotes tau enrichment and facilitates disease progress. read more

  1. Cat.No. Product Name Information
  2. A8200 DAPT (GSI-IX) DAPT (GSI-IX) is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells.
  3. A8190 Semagacestat (LY450139) Semagacestat (also known as LY450139), [(2S)-2-hydroxy-N-((2S)-1-((1S)-3-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1ylamino)-1-oxopropan-2-yl)-3-methylbutanamide] is an azepine class γ-secretase, which is currently being investigated as a potential disease-modifying agent for the treatment of Alzheimer’s disease (AD).
  4. A1932 (-)-Huperzine A (-)-Huperzine A is a natural product that acts as an and NMDA receptor antagonist and reversible inhibitor of AChE (acetylcholinesterase), the enzyme primarily responsible for degradation of the neurotransmitter acetylcholine and termination of the acetylcholine synaptic signal.
  5. A1102 Amyloid β-peptide (10-35), amide Amyloid β-protein (10-35) was used as a trunCated peptide model for the full-length amyloid β-proteins (1-40) and (1-42) in high-resolution structural studies.
  6. A1053 amyloid A protein fragment [Homo sapiens] Amyloid A proteins (H2N-Ala-Gly-Leu-Pro-Glu-Lys-Tyr-OH), also called Serum amyloid A (SSA) proteins, are a family of apolipoproteins associated with high-density lipoprotein (HDL) in plasma.
  7. A1031 Myelin Basic Protein (68-82), guinea pig Myelin Basic Protein (68-82), guinea pig,(C71H113N23O28), a peptide with the sequence Tyr-Gly-Ser-Leu-Pro-Gln-Lys-Ser-Gln-Arg-Ser-Gln-Asp-Glu-Asn, MW= 1736.79.
  8. A1005 Beta-Sheet Breaker Peptide iAβ5 Beta-Sheet Breaker Peptide iAβ5 (C33H43N5O8), with the sequence H-Leu-Pro-Phe-Phe-Asp-OH, has been shown to inhibit amyloidogenesis in rat brain models.
  9. A1004 Amyloid Precursor C-Terminal Peptide Amyloid precursor c-terminal peptide (APP) (C86H118N20O27S) has the amino acid sequence Gly-Tyr-Glu-Asn-Pro-Thr-Tyr-Lys-Phe-Phe-Glu-Gln-Met-Gln-Asn.
  10. A1003 Amyloid β-Protein (1-15) Beta-amyloid protein (A beta), a 39-43 amino acid peptide composed of a portion of the transmembrane domain and the extracellular domain of the amyloid precursor protein (APP), is also the principal component of amyloid.
  11. A1002 Beta-Amyloid (1-11) Beta-amyloid (1-11) (Abeta or Aβ) (C56H76N16O22) is a peptide with the sequence H-{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}-OH,which is processed from the Amyloid precursor protein.

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