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Alzheimer

Alzheimer

Alzheimer’s disease (AD), a neurodegenerative disorder, is the most common cause of progressive dementia. Two microscopic characteristics of AD are extracellular amyloid plaques and intracellular neurofibrillary tangles. Amyloid β peptide (Aβ), derived from amyloid precursor protein (APP) by sequential protein cleavage, and other metabolites deposit around neurons and form amyloid plaques, which contribute to the disease’s pathogenesis. The neurofibrillary tangles are formed by the aggregation of phosphorylated tau proteins. Under pathogenic conditions, tau accumulates in dendritic spines and interferes with neurotransmission. The Aβoligomer promotes tau enrichment and facilitates disease progress. read more

product-structure
  1. Cat.No. Product Name Information
  2. A1932 (-)-Huperzine A NMDA receptor antagonist/AChE inhibitor
  3. A1053 amyloid A protein fragment [Homo sapiens] Apolipoproteins related to HDL in plasma
  4. A1124 Amyloid Beta-Peptide (1-40) (human) Amyloid precursor protein
  5. A1123 Amyloid Beta-Peptide (12-28) (human) sequence H2N-VHHQKLVFFAEDVGSNK-OH
  6. A1039 Amyloid Beta-peptide (25-35) (human) Functional domain of Aβ
  7. A1004 Amyloid Precursor C-Terminal Peptide For beta amyloid generation
  8. A1038 Amyloid β-Peptide (10-20) (human) Initiates neurodegeneration in Alzheimer disease
  9. A1102 Amyloid β-peptide (10-35), amide Truncated peptide model
  10. A1003 Amyloid β-Protein (1-15) Principal component of amyloid
  11. A1002 Beta-Amyloid (1-11) Amyloidogenic peptide

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