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Alzheimer

Alzheimer

Alzheimer’s disease (AD), a neurodegenerative disorder, is the most common cause of progressive dementia. Two microscopic characteristics of AD are extracellular amyloid plaques and intracellular neurofibrillary tangles. Amyloid β peptide (Aβ), derived from amyloid precursor protein (APP) by sequential protein cleavage, and other metabolites deposit around neurons and form amyloid plaques, which contribute to the disease’s pathogenesis. The neurofibrillary tangles are formed by the aggregation of phosphorylated tau proteins. Under pathogenic conditions, tau accumulates in dendritic spines and interferes with neurotransmission. The Aβoligomer promotes tau enrichment and facilitates disease progress. read more

Biochemicals

  1. Cat.No. Product Name Information
  2. A1932 (-)-Huperzine A Top Seller NMDA receptor antagonist/AChE inhibitor
  3. A8190 Semagacestat (LY450139) Top Seller γ-secretase inhibitor
  4. A8200 DAPT (GSI-IX) Top Seller γ-secretase inhibitor,potent and specific

Bioactive Peptides

  1. Cat.No. Product Name Information
  2. A1053 amyloid A protein fragment [Homo sapiens] Apolipoproteins related to HDL in plasma
  3. A1031 Myelin Basic Protein (68-82), guinea pig Myelin Basic Protein
  4. A1005 Beta-Sheet Breaker Peptide iAβ5 Peptide which can inhibit amyloidogenesis
  5. A1004 Amyloid Precursor C-Terminal Peptide For beta amyloid generation
  6. A1003 Amyloid β-Protein (1-15) Principal component of amyloid
  7. A1002 Beta-Amyloid (1-11) Amyloidogenic peptide
  8. A1131 COG 133 ApoE mimetic peptide
  9. A1124 Amyloid Beta-Peptide (1-40) (human) Amyloid precursor protein
  10. A1123 Amyloid Beta-Peptide (12-28) (human) sequence H2N-VHHQKLVFFAEDVGSNK-OH
  11. A1040 Myelin Basic Protein (87-99) Encephalitogenic peptide
  12. A1039 Amyloid Beta-peptide (25-35) (human) Functional domain of Aβ
  13. A1038 Amyloid β-Peptide (10-20) (human) Initiates neurodegeneration in Alzheimer disease
  14. A1102 Amyloid β-peptide (10-35), amide Truncated peptide model