Thymidylate synthase (TS) is an enzyme catalyzing the sole de novo pathway for the biosynthesis of deoxythymidine monophosphate (dTMP) in which deoxyuridine monophosphate (dUMP) is reductively methylated by 5,10-methylenetetrahydrofolate (CH2H4folate) with the generation of dTMP and dihydrofolate (H2folate). TS has been found in a wide range of sources, including bacteria, bacteriophage, yeast, viruses and vertebrates, where it is usually a dimer consisting of identical subunits (30 to 35 kDa each). However, protozoal TS is a bifunctional protein with dihydrofolate reductase (DHFR) on the same polypeptide chain, where TS and DHFR domains are located on the carboxy terminus and amino terminus respectively.
- Cat.No. Product Name Information
- B2092 Doxifluridine oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU)
- B5892 Nolatrexed (AG-337) Non-classical thymidylate synthase inhibitor
- A4390 Pemetrexed TS, DHFR,GARFT and AICARFT inhibitor
- A3707 Pemetrexed disodium hemipenta hydrate Antifolate and antimetabolite agent
- A8542 Triflurdine (Viroptic) Anti-herpesvirus antiviral drug