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DiscoveryProbe™ MAPK Signaling Pathway Compounds Panel

DiscoveryProbe™ MAPK Signaling Pathway Compounds Panel

Catalog No. L1020
Size Price Stock Qty
5mg/well $3,780.00 In stock

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Sample solution is provided at 25 µL, 10mM.

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Featured Products of the Panel

Catalog No. Product Name Summary Targets CAS Number Smiles
A3943 XMD8-92 BMK1/ERK5 inhibitor,highly selective MAPK Signaling|ERK 1234480-50-2 CCOC1=C(C=CC(=C1)N2CCC(CC2)O)NC3=NC=C4C(=N3)N(C5=CC=CC=C5C(=O)N4C)C
A3519 JNK-IN-7 Selective JNK inhibitor MAPK Signaling|JNK 1408064-71-0 CN(C)CC=CC(=O)NC1=CC=CC(=C1)C(=O)NC2=CC=C(C=C2)NC3=NC=CC(=N3)C4=CN=CC=C4
A1947 MEK162 (ARRY-162, ARRY-438162) MEK1/2 inhibitor,potent and selective MAPK Signaling|MEK1/2 606143-89-9 CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)F)C(=O)NOCCO
A3004 Vemurafenib (PLX4032, RG7204) BRAF kinase inhibitor MAPK Signaling|MEK1/2 918504-65-1 CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)C4=CC=C(C=C4)Cl)F
A3805 SCH772984 Novel ERK1 and ERK2 inhibitor MAPK Signaling|MEK1/2 942183-80-4 C1CN(CC1C(=O)NC2=CC3=C(C=C2)NN=C3C4=CC=NC=C4)CC(=O)N5CCN(CC5)C6=CC=C(C=C6)C7=NC=CC=N7
A5801 BIX 02189 Selective MEK5 inhibitor MAPK Signaling|MEK1/2 1094614-85-3 CN(C)CC1=CC(=CC=C1)NC(=C2C3=C(C=C(C=C3)C(=O)N(C)C)NC2=O)C4=CC=CC=C4
Download the MAPK Signaling Pathway Compounds Panel - XLSX       Download the MAPK Signaling Pathway Compounds Panel - SDF

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Related Biological Data

LY2228820

Related Biological Data

LY2228820

Related Biological Data

GSK1120212
GSK1120212 causes sustained inhibition of ERK1/2 phosphorylation, and differential effects on MEK phosphorylation. SK-MEL-28 and A-375P(F11) (BRAF-mutant) cell lines were treated with 250 nmol/L GSK1120212 (Trametinib) and harvested at the indicated time points.

Related Biological Data

PLX4032
PLX4032 decreases pERK levels and inhibits growth of D4M cells. (A, B) Immunoblots of 2.5 μg of protein lysate for pERK or pAKT from (A) D4M.3A and (B) VMM5 cells, treated with DMSO, 3 μM PLX4032, or 10 μM U0126 over a time course (minutes post-treatment). Total ERK and total AKT were used as loading controls.

Related Biological Data

Dabrafenib
Growth of Colo 205 tumor xenografts was measured in mice during and for a period following oral q.d. x 14 treatment with 0, 3, 10, 30, and 100 mg/kg dabrafenib. Mean tumor volumes are plotted with their standard error mean and 4 partial regressions out of 8 mice were observed at the 100 mg/kg dose after the 14-day treatment period. The 14-day period of dosing is indicated by the shaded gray bar.

Signaling Pathway

P38 Compare Products
Paf Compare Products
MEK1/2 Research Area
MEK1/2 Compare Products

Advantages

  • Available in stock with overnight delivery and free shipping over $500
  • Cost-effective and competitive price to save your findings
  • Potent, selective and cell-permeable in inhibiting or activating target molecules
  • Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.)
  • Detailed files describing potency, selectivity and applications etc.
  • Supported by published data from top peer-reviewed journals
  • Guaranteed high quality with NMR and HPLC validation

Storage and Shipping Information

Solubility Soluble in DMSO Storage Desiccate at -20°C
Packaging 96 well plate Form Powder
General tips For obtaining a higher solubility , please warm the tube at 37°C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

A wide range of well-characterized bioactive molecules that covers various targets on the MAPK signaling pathway, including MEK1/2, p38 and Raf etc. Facilitate your research towards the insights of cell proliferation, differentiation, apoptosis and motility etc. Applicable in cellular assays, animal models and drug screenings etc.

References

1. Plotnikov A, Zehorai E, Procaccia S, Seger R. The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation. Biochim Biophys Acta. 2011 Sep;1813(9):1619-33.
Abstract
The MAPK cascades are central signaling pathways that regulate a wide variety of stimulated cellular processes, including proliferation, differentiation, apoptosis and stress response. In this review, we briefly cover the composition of the MAPK cascades, as well as their physiological and pathological functions. The nuclear translocation of signaling components may emerge as an important regulatory layer in the induction of cellular processes, and therefore, may serve as targets for therapeutic intervention in signaling-related diseases such as cancer and diabetes.