DiscoveryProbe™ Immunology/Inflammation-related Compounds Panel
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
SYBR Safe DNA Gel Stain
Safe and sensitive stain for visualization of DNA or RNA in agarose or acrylamide gels.
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Featured Products of the Panel
|Catalog No.||Product Name||Summary||Targets||CAS Number||Smiles|
|A3850||TAK-242||TLR 4 signaling inhibitor||Immunology/Inflammation|TLR||243984-11-4||CCOC(=O)C1=CCCCC1S(=O)(=O)NC2=C(C=C(C=C2)F)Cl|
|A3248||BMS-345541||IKK inhibitor,highly selective||NF-κB|IκB/IKK||547757-23-3||CC1=CC2=C(C=C1)N=C(C3=NC=C(N23)C)NCCN.Cl|
|A3628||MLN120B||IκB Kinase β Inhibitor||NF-κB|IκB/IKK||783348-36-7||CC1=C(C=CC=N1)C(=O)NC2=C3C(=CC(=C2OC)Cl)C4=C(N3)C=NC=C4|
|B1585||SC-514||ATP-competitive IKK-2 inhibitor, orally active||NF-κB|IκB/IKK||354812-17-2||C1=CSC=C1C2=CC(=C(S2)C(=O)N)N|
|B3033||Bay 11-7085||NK-κB activation inhibitor||NF-κB|IκB/IKK||196309-76-9||CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)C=CC#N|
|N1855||Andrographolide||NF-κB signaling Inhibitor||NF-κB|IκB/IKK||5508-58-7||CC12CCC(C(C1CCC(=C)C2CC=C3C(COC3=O)O)(C)CO)O|
|A4217||QNZ (EVP4593)||Potent NF-κB inhibitor||NF-κB|NF-κB||545380-34-5||C1=CC=C(C=C1)OC2=CC=C(C=C2)CCNC3=NC=NC4=C3C=C(C=C4)N|
|Download the Immunology/Inflammation-related Compounds Panel - XLSX Download the Immunology/Inflammation-related Compounds Panel - SDF|
TLR(Toll-like receptor)-mediated recognition of components derived from a wide range of pathogens and their role in the subsequent initiation of innate immune responses is widely accepted; however, the recent discovery of non-TLR PRRs(pattern recognition receptors), such as C-type lectin receptors, NOD-like receptors, and RIG-I-like receptors, suggests that many aspects of innate immunity are more sophisticated and complex. In this review, we will focus on the role played by TLRs in mounting protective immune responses against infection and their crosstalk with other PRRs with respect to pathogen recognition.