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c-Myc tag PeptideSynthetic peptide tag

c-Myc tag Peptide

Catalog No. A6003
Size Price Stock Qty
5mg $60.00 In stock
25mg $270.00 In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical structure

c-Myc tag Peptide

Related Biological Data

c-Myc tag Peptide

Biological Activity

Description c-Myc tag Peptide is a synthetic peptide corresponding to the C-terminal amino acids (410-419) of human c-myc protein.
Targets anti-c-Myc antibody          
IC50            

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Chemical Properties

Cas No. SDF Download SDF
Synonyms H-Glu-Gln-Lys-Leu-Ile-Ser-Glu-Glu-Asp-Leu-OH
Chemical Name c-Myc Peptide
Canonical SMILES N[C@@H](CCC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H]([C@H](C)CC)C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Formula C51H86N12O21 M.Wt 1203.3
Solubility Soluble in water or 1% acetic acid Storage Desiccate at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

Background

c-Myc Peptide is a useful displacement of c-Myc-tagged fusion proteins bound to anti-c-Myc antibodies in immunoassays. The successful inhibition of antibody binding by c-Myc peptide demonstrates binding is specific. c-Myc peptide participates in regulation of growth-related gene transcription.

The c-Myc Peptide is a synthetic peptide with an amino acid sequence that corresponds to the amino acids 410-419 of the C-terminal of human c-myc. Myc (c-Myc) is a regulator gene that codes for a transcription factor. c-Myc activation results in numerous biological effects. The first to be discovered was its capability to drive cell proliferation (upregulates cyclins, downregulates p21), but it also plays a very important role in regulating cell growth (upregulates ribosomal RNA and proteins), apoptosis (downregulates Bcl-2), differentiation and stem cell self-renewal. C-Myc is a very strong proto-oncogene and it is very often found to be upregulated in many types of cancers. c-Myc overexpression stimulates gene amplification, [1] presumably through DNA over-replication.

References:
1. Denis N, Kitzis A, Kruh J, Dautry F, Corcos D (August 1991). "Stimulation of methotrexate resistance and dihydrofolate reductase gene amplification by c-myc". Oncogene 6 (8): 1453–7.