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HER2

HER2 is a member of the epidermal growth factor. It initiates the EGF downstream cascade by forming a heterodimer with other ligand-bound EGF receptor. It is associated with breast and ovarian cancers.

A1835 Pelitinib (EKB-569)

Summary: EGFR inhibitor,potent and irreversible

insoluble in EtOH; insoluble in H2O; ≥11.7 mg/mL
A2822 AC480 (BMS-599626)

Target: EGFR

Summary: HER1/2 inhibitor,selective and efficacious

≥28.35 mg/mL
A8322 Neratinib (HKI-272)
1 Citation

Target: EGFR

Summary: HER2/EGFR inhibitor,potent and irreversible

insoluble in H2O; ≥13.93 mg/mL
A8528 TAK-285

Target: EGFR|HER2

Summary: HER2/EGFR(HER1) inhibitor

≥27.4 mg/mL