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mTOR

MTOR (mechanistic target of rapamycin) is a serine/threonine kinase that regulates cellular metabolism, growth ad survival. It mediates the cellular response to stress, growth factor and hormone etc. It is involved in cancer, aging and neurodegenerative diseases etc.

Items 11-20 of 29

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  1. WYE-125132 (WYE-132)
    B1642 WYE-125132 (WYE-132)
    Target: mTOR
    Summary: ATP-competitive mTOR inhibitor, highly potent
      insoluble in EtOH; insoluble in H2O; ≥13 mg/mL
  2. OSI-027
    B1637 OSI-027
    Summary: MTORC1/ mTORC2 inhibitor
      insoluble in EtOH; insoluble in H2O; ≥32.5 mg/mL
  3. Torin 2
    B1640 Torin 2
     1 Citation
    Target: mTOR|DNA-PK|ATM/ATR
    Summary: MTOR inhibitor,highly potent and selective
      ≥21.6 mg/mL
  4. GDC-0980 (RG7422)
    B2184 GDC-0980 (RG7422)
    Summary: Class I PI3K inhibitor for PI3Kα/β/δ/γ
      ≥21.35 mg/mL
  5. Rapalink-1
    A8764 Rapalink-1
    Target: mTOR
    Summary: third-generation mTOR inhibitor
      ≥178.4 mg/mL
  6. GNE-493
    B8000 GNE-493
    Summary: Pan-PI3K/mTOR inhibitor
      Soluble in DMSO
  7. GNE-477
    B8001 GNE-477
    Summary: dual PI3K/mTOR inhibitor
      insoluble in H2O; insoluble in EtOH; ≥16.69 mg/mL
  8. MHY1485
    B5853 MHY1485
     2 Citation
    Target: mTOR
    Summary: mTOR activator, autophage inhibitor
      insoluble in EtOH; insoluble in H2O; ≥19.35 mg/mL
  9. CC-223
    B6171 CC-223
    Summary: mTOR inhibitor, orally bioavailable
      insoluble in H2O; ≥108 mg/mL
  10. OXA-01
    C4204 OXA-01
    Summary: mTORC1 and mTORC2 inhibitor
      ≤3 mg/mL

Items 11-20 of 29

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