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RAR/RXR

RAR/RXR is a heterodimer of RAR (retinoic acid receptor) and RXR (retinoid X receptor) that cause dissociation of corepressor and recruitment of coactivator protein that, in turn, promotes transcription of the downstream target gene into mRNA and eventually protein.

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  1. Acitretin
    A2415 Acitretin
    Target: RARs
    Summary: Metabolite of etretinate
      insoluble in EtOH; insoluble in H2O; ≥16.32 mg/mL
  2. Palovarotene
    B1175 Palovarotene
    Target: RARs
    Summary: Selective retinoic acid receptor gamma(RAR-γ) agonist
      ≥41.5 mg/mL
  3. AM580
    B4654 AM580
    Target: RARs
    Summary: Selective RARα agonist
      insoluble in H2O; ≥14.3 mg/mL
  4. AGN 194310
    B4702 AGN 194310
     1 Citation
    Target: RARs
    Summary: pan-RAR antagonist
      insoluble in H2O; ≥16.8 mg/mL
  5. Fenretinide
    A3412 Fenretinide
    Target: FAK
    Summary: Synthetic retinoid agonist
      insoluble in H2O; ≥19.6 mg/mL

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