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CFTR

CFTR (cystic fibrosis transmembrane conductance regulator) is an ABC transporter-class ion channel that conducts chloride[3] and thiocyanate[4] ions across epithelial cell membranes.

5 Items

per page
  1. VX-661
    A2664 VX-661
    Target: CFTR
    Summary: F508del CFTR corrector
      ≥21.8 mg/mL
  2. VX-809
    A8351 VX-809
    Target: CFTR
    Summary: CFTR corrector
      ≥22.6 mg/mL
  3. PTC124 (Ataluren)
    A8553 PTC124 (Ataluren)
    Summary: CFTR-G542X nonsense allele inhibitor
      insoluble in H2O; ≥10.6 mg/mL
  4. IOWH-032
    A8637 IOWH-032
    Target: CFTR
    Summary: CFTR inhibitor
      ≥21.85 mg/mL
  5. GlyH-101
    B1087 GlyH-101
    Target: CFTR
    Summary: CFTR Inhibitor II
      insoluble in H2O; insoluble in EtOH; ≥20.35 mg/mL

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Specificity
  1. Selective4item
Reversibility
  1. Reversible1 item
Target
  1. CFTR4item