Cell Cycle/Checkpoint
The cell cycle is consisted of 4 main phases: Gap 1 (G1), DNA replication (S), Gap 2 (G2), and mitosis (M). There are “checkpoints” mechanism regulates the transition between these phases, at the G1/S boundary, in the S-phase and during G2/M phases. Cell can only pass through these checkpoints when signaling factors are activated and free of DNA damage. Important proteins that control cell cycle events and checkpoints are cullins, cyclins, cyclin-dependent kinases (Cdks), p53 and their inhibitors etc. Cdks family (Cdk2, Cdk3, Cdk4 and Cdk6) are Ser/Thr kinases that regulate cell cycle progression in association with cyclin binding partners (cyclin D, cyclin E and cyclin A) during all four phases. p53 halts the cell cycle if the DNA is damaged and allowing time for DNA repair to progress; it can also initiate apoptosis if DNA damage is too severe to be repaired.
- A4112 Barasertib (AZD1152-HQPA)3 CitationTarget: Aurora KinasesSummary: Aurora Kinase B inhibitor, Potent and selective
- A3760 ReversineTarget: Aurora KinasesSummary: A3 adenosine receptor antagonist,ARK-1/-2/-3 inhibitor
- A1980 SNS-032 (BMS-387032)2 CitationTarget: Cyclin-Dependent KinasesSummary: CDK inhibitor
- A8316 PD 0332991 (Palbociclib) HCl5 CitationTarget: Cyclin-Dependent KinasesSummary: CDK4/6 inhibitor,highly selective
- A8335 Palbociclib (PD0332991) Isethionate1 CitationTarget: Cyclin-Dependent KinasesSummary: CDK4/6 inhibitor,highly selective
- A8477 MK-8776 (SCH-900776)Target: ChkSummary: Chk1 inhibitor,potent and selective